Cefalotin

Cefalotin

Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682860
Pregnancy category	AU: A US: B (No risk in non-human studies)
Routes of administration	Intravenous
ATC code	J01DB03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	n/a
Protein binding	65 to 80%
Metabolism	Hepatic
Elimination half-life	30 minutes to 1 hour
Excretion	Renal
Identifiers
IUPAC name (6R,7R)-3-[(acetoxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number	153-61-7 Y
PubChem CID	6024
DrugBank	DB00456 Y
ChemSpider	5802 Y
UNII	R72LW146E6
KEGG	D07635 Y
ChEBI	CHEBI:124991 Y
ChEMBL	ChEMBL617 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H16N2O6S2
Molar mass	396.44 g/mol
3D model (JSmol)	Interactive image
SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cc3sccc3)COC(=O)C)C(=O)O
InChI InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1 Y Key:XIURVHNZVLADCM-IUODEOHRSA-N Y
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Evidence Based Medicine
Cochrane Collaboration on Cefalotin Bandolier on Cefalotin TRIP on Cefalotin
Clinical Trials
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Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Cefalotin NICE Guidance on Cefalotin NHS PRODIGY Guidance FDA on Cefalotin CDC on Cefalotin
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Commentary
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Definitions
Definitions of Cefalotin
Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
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International
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cefalotin (INN) (Template:PronEng) or cephalothin (USAN) (Template:IPA) is a first-generation cephalosporin antibiotic. It was the first cephalosporin marketed and continues to be widely used. It is an intravenously-administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is commonly marketed under the trade name Keflin (Lilly).

See also

• Cephalosporin
• Cefalexin