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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.[1][2][3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions.[4] Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.[5] Alternate splice variants for this gene have been described, but their biological validity has not been determined.[6]


  1. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (February 1998). "Purification, characterization, and cloning of enamel matrix serine proteinase 1". Journal of Dental Research. 77 (2): 377–86. doi:10.1177/00220345980770020601. PMID 9465170.
  2. Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression". Proceedings of the National Academy of Sciences of the United States of America. 96 (6): 3114–9. doi:10.1073/pnas.96.6.3114. PMC 15904. PMID 10077646.
  3. Stephenson SA, Verity K, Ashworth LK, Clements JA (August 1999). "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4". The Journal of Biological Chemistry. 274 (33): 23210–4. doi:10.1074/jbc.274.33.23210. PMID 10438493.
  4. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
  5. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000). "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors". Gene. 251 (1): 1–8. doi:10.1016/S0378-1119(00)00203-1. PMID 10863090.
  6. "Entrez Gene: KLK4 kallikrein-related peptidase 4".

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.251