Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined.[3]
References
↑Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID16800724.
↑Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID16800723.
Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID10969073.
Yousef GM, Magklara A, Chang A, et al. (2001). "Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies". Cancer Res. 61 (8): 3425–31. PMID11309303.
Hooper JD, Bui LT, Rae FK, et al. (2001). "Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle". Genomics. 73 (1): 117–22. doi:10.1006/geno.2000.6490. PMID11352573.
Yousef GM, Stephan C, Scorilas A, et al. (2003). "Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues". Prostate. 56 (4): 287–92. doi:10.1002/pros.10263. PMID12858357.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID15057824.
Brattsand M, Stefansson K, Lundh C, et al. (2005). "A proteolytic cascade of kallikreins in the stratum corneum". J. Invest. Dermatol. 124 (1): 198–203. doi:10.1111/j.0022-202X.2004.23547.x. PMID15654974.
Felber LM, Borgoño CA, Cloutier SM, et al. (2005). "Enzymatic profiling of human kallikrein 14 using phage-display substrate technology". Biol. Chem. 386 (3): 291–8. doi:10.1515/BC.2005.035. PMID15843175.
Stefansson K, Brattsand M, Ny A, et al. (2006). "Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum". Biol. Chem. 387 (6): 761–8. doi:10.1515/BC.2006.095. PMID16800737.
Borgoño CA, Michael IP, Shaw JL, et al. (2007). "Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14". J. Biol. Chem. 282 (4): 2405–22. doi:10.1074/jbc.M608348200. PMID17110383.
Borgoño CA, Michael IP, Komatsu N, et al. (2007). "A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation". J. Biol. Chem. 282 (6): 3640–52. doi:10.1074/jbc.M607567200. PMID17158887.
External links
The MEROPS online database for peptidases and their inhibitors: S01.029
