Isoprostane

Jump to navigation Jump to search

WikiDoc Resources for Isoprostane

Articles

Most recent articles on Isoprostane

Most cited articles on Isoprostane

Review articles on Isoprostane

Articles on Isoprostane in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Isoprostane

Images of Isoprostane

Photos of Isoprostane

Podcasts & MP3s on Isoprostane

Videos on Isoprostane

Evidence Based Medicine

Cochrane Collaboration on Isoprostane

Bandolier on Isoprostane

TRIP on Isoprostane

Clinical Trials

Ongoing Trials on Isoprostane at Clinical Trials.gov

Trial results on Isoprostane

Clinical Trials on Isoprostane at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Isoprostane

NICE Guidance on Isoprostane

NHS PRODIGY Guidance

FDA on Isoprostane

CDC on Isoprostane

Books

Books on Isoprostane

News

Isoprostane in the news

Be alerted to news on Isoprostane

News trends on Isoprostane

Commentary

Blogs on Isoprostane

Definitions

Definitions of Isoprostane

Patient Resources / Community

Patient resources on Isoprostane

Discussion groups on Isoprostane

Patient Handouts on Isoprostane

Directions to Hospitals Treating Isoprostane

Risk calculators and risk factors for Isoprostane

Healthcare Provider Resources

Symptoms of Isoprostane

Causes & Risk Factors for Isoprostane

Diagnostic studies for Isoprostane

Treatment of Isoprostane

Continuing Medical Education (CME)

CME Programs on Isoprostane

International

Isoprostane en Espanol

Isoprostane en Francais

Business

Isoprostane in the Marketplace

Patents on Isoprostane

Experimental / Informatics

List of terms related to Isoprostane


The isoprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily arachidonic acid) without the direct action of cyclooxygenase (COX) enzyme. [1][2] These nonclassical eicosanoids possess potent biological activity as inflammatory mediators that augment the perception of pain.[3] These compounds are accurate markers of lipid peroxidation in both animal and human models of oxidative stress.

Abundance

Polyunsaturated fatty acids other than arachidonic acid are also vulnerable to reactive oxygen species and produce isoprostanes.

For example, in addition to the four classes of F2-isoprostanes that can arise from arachidonic acid, peroxidation of eicosapentaenoic acid (EPA) is predicted to lead to the generation of six classes of F3 isoprostanes, α-linolenic and γ-linolenic acids to two classes of E1- and F1-isoprostanes, and docosahexaenoic acid to eight classes of D4-isoprostanes and eight classes of E4-isoprostanes. Each of the classes comprise up to eight racemic isomers, leading to an astounding number of isoprostane molecules!

—LJ Janssen[4]

References

  1. COX activity produces H2O2 which may non-enzymatically produce isoprostanes.
  2. Morrow JD, Roberts LJ (1996). "The isoprostanes. Current knowledge and directions for future research". Biochem. Pharmacol. 51 (1): 1–9. PMID 8534261. |access-date= requires |url= (help)
  3. Evans AR, Junger H, Southall MD; et al. (2000). "Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons". J. Pharmacol. Exp. Ther. 293 (3): 912–20. PMID 10869392.
  4. Janssen LJ (2001). "Isoprostanes: an overview and putative roles in pulmonary pathophysiology". Am. J. Physiol. Lung Cell Mol. Physiol. 280 (6): L1067–82. PMID 11350785. Retrieved 2007-11-02.


Template:WH Template:WikiDoc Sources