Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3gene.[1][2]
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[3]
References
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↑Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. doi:10.1126/science.281.5379.998. PMID9703517.
Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis". Apoptosis. 8 (1): 11–8. doi:10.1023/A:1021688600370. PMID12510147.
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Schäfer H, Trauzold A, Siegel EG, et al. (1996). "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line". Cancer Res. 56 (11): 2641–8. PMID8653710.
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
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Schäfer H, Diebel J, Arlt A, et al. (1998). "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB". FEBS Lett. 436 (2): 139–43. doi:10.1016/S0014-5793(98)01109-0. PMID9781666.
Kobayashi T, Pittelkow MR, Warner GM, et al. (1998). "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3". Biochem. Biophys. Res. Commun. 251 (3): 868–73. doi:10.1006/bbrc.1998.9556. PMID9791001.
Kumar R, Kobayashi T, Warner GM, et al. (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes". Biochem. Biophys. Res. Commun. 253 (2): 336–41. doi:10.1006/bbrc.1998.9692. PMID9878538.
Schäfer H, Arlt A, Trauzold A, et al. (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo". Biochem. Biophys. Res. Commun. 262 (1): 139–45. doi:10.1006/bbrc.1999.1131. PMID10448082.
Feldmann KA, Pittelkow MR, Roche PC, et al. (2001). "Expression of an immediate early gene, IEX-1, in human tissues". Histochem. Cell Biol. 115 (6): 489–97. doi:10.1007/s004180100284. PMID11455449.
Ohki R, Yamamoto K, Mano H, et al. (2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays". J. Hypertens. 20 (4): 685–91. doi:10.1097/00004872-200204000-00026. PMID11910304.
Im HJ, Craig TA, Pittelkow MR, Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression". Oncogene. 21 (23): 3706–14. doi:10.1038/sj.onc.1205450. PMID12032839.
