Serine/threonine-protein kinase, Intestinal cell kinase or ICK [1] enzyme that in humans is encoded by the ICK gene .[2] [3]
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases . This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases . The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation . Alternative splicing has been observed at this locus and two variants, encoding the same isoform , have been identified.[3]
References Further reading
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res . 6 (1): 63–70. doi :10.1093/dnares/6.1.63 . PMID 10231032 . Togawa K, Yan YX, Inomoto T, et al. (2000). "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases". J. Cell. Physiol . 183 (1): 129–39. doi :10.1002/(SICI)1097-4652(200004)183:1<129::AID-JCP15>3.0.CO;2-S . PMID 10699974 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature . 425 (6960): 805–11. doi :10.1038/nature02055 . PMID 14574404 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Fu Z, Schroeder MJ, Shabanowitz J, et al. (2005). "Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase" . Mol. Cell. Biol . 25 (14): 6047–64. doi :10.1128/MCB.25.14.6047-6064.2005 . PMC 1168834 PMID 15988018 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
