Hypergammaglobulinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
History
- A positive family history of hypergammaglobulinemia may be present.
- History of severe and/or recurrent bacterial respiratory and gastrointestinal infections as well as opportunistic infections may be present in patients with x-linked hyper-IgM.
Symptoms
Type 1 Hyper-IgM Immunodeficiency
- The majority of patients with x-linked hyper-IgM are symptomatic by infancy.[1]
- Symptoms of type 1 hyper-IgM immunodeficiency are a result of infection and may include the following:
- Fever
- Cough
- Tachypnea
- Dyspnea
- Diarrhea
- Other symptoms may include:
- Pruritis
References
- ↑ Fried AJ, Bonilla FA (2009). "Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections". Clin Microbiol Rev. 22 (3): 396–414. doi:10.1128/CMR.00001-09. PMC 2708392. PMID 19597006.