HSD17B14

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17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.^[1]^[2]

17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of androgens and estrogens using NAD(P)(H) as a cofactor. It is primarily expressed in glandular epithelial tissues of breast, ovary, and testis.^[3]

References

↑ Zhu Y, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition". In Lightman S. Hormones, Brain and Behavior. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2.
↑ Zanders ED (9 November 2015). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. pp. 257–. ISBN 978-1-118-84985-9.
↑ Sivik T, Vikingsson S, Gréen H, Jansson A (2012). "Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues". Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 44 (13): 949–56. doi:10.1055/s-0032-1321815. PMID 22864907.

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[Elsevier2016-1] Zhu Y, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition". In Lightman S. Hormones, Brain and Behavior. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2.

[Zanders2015-2] Zanders ED (9 November 2015). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. pp. 257–. ISBN 978-1-118-84985-9.

[pmid22864907-3] Sivik T, Vikingsson S, Gréen H, Jansson A (2012). "Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues". Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 44 (13): 949–56. doi:10.1055/s-0032-1321815. PMID 22864907.

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HSD17B14

References

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