HAPLN1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Hyaluronan and proteoglycan link protein 1 is a protein that in humans is encoded by the HAPLN1 gene.

Interactions

HAPLN1 has been shown to interact with Versican.

Further reading

• Mundlos S, Meyer R, Yamada Y, Zabel B (1992). "Distribution of cartilage proteoglycan (aggrecan) core protein and link protein gene expression during human skeletal development". Matrix. 11 (5): 339–46. doi:10.1016/s0934-8832(11)80205-2. PMID 1725805.
• Rhodes C, Savagner P, Line S, et al. (1991). "Characterization of the promoter for the rat and human link protein gene". Nucleic Acids Res. 19 (8): 1933–9. doi:10.1093/nar/19.8.1933. PMC 328126. PMID 2030970.
• Dudhia J, Hardingham TE (1990). "The primary structure of human cartilage link protein". Nucleic Acids Res. 18 (8): 2214. doi:10.1093/nar/18.8.2214. PMC 330736. PMID 2336413.
• Perkins SJ, Nealis AS, Dudhia J, Hardingham TE (1989). "Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein". J. Mol. Biol. 206 (4): 737–53. doi:10.1016/0022-2836(89)90580-9. PMID 2738916.
• Nguyen Q, Murphy G, Hughes CE, et al. (1993). "Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein". Biochem. J. 295. ( Pt 2): 595–8. PMC 1134922. PMID 7694569.
• Dudhia J, Bayliss MT, Hardingham TE (1994). "Human link protein gene: structure and transcription pattern in chondrocytes". Biochem. J. 303. ( Pt 1): 329–33. PMC 1137594. PMID 7945259.
• Guerassimov A, Zhang Y, Banerjee S, et al. (1998). "Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis". J. Rheumatol. 25 (8): 1480–4. PMID 9712087.
• Perveen R, Hart-Holden N, Dixon MJ, et al. (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3". Genomics. 57 (2): 219–26. doi:10.1006/geno.1999.5766. PMID 10198161.
• Hirakawa S, Oohashi T, Su WD, et al. (2000). "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain". Biochem. Biophys. Res. Commun. 276 (3): 982–9. doi:10.1006/bbrc.2000.3583. PMID 11027579.
• Pokharna HK, Pottenger LA (2000). "Glycation induced crosslinking of link proteins, in vivo and in vitro". J. Surg. Res. 94 (1): 35–42. doi:10.1006/jsre.2000.6000. PMID 11038300.
• Milz S, Schlüter T, Putz R, et al. (2001). "Fibrocartilage in the transverse ligament of the human atlas". Spine. 26 (16): 1765–71. doi:10.1097/00007632-200108150-00007. PMID 11493848.
• Sun GW, Kobayashi H, Suzuki M, et al. (2003). "Production of cartilage link protein by human granulosa-lutein cells". J. Endocrinol. 175 (2): 505–15. doi:10.1677/joe.0.1750505. PMID 12429048.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Spicer AP, Joo A, Bowling RA (2003). "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links". J. Biol. Chem. 278 (23): 21083–91. doi:10.1074/jbc.M213100200. PMID 12663660.
• Matsumoto K, Shionyu M, Go M, et al. (2003). "Distinct interaction of versican/PG-M with hyaluronan and link protein". J. Biol. Chem. 278 (42): 41205–12. doi:10.1074/jbc.M305060200. PMID 12888576.
• Shi S, Grothe S, Zhang Y, et al. (2004). "Link protein has greater affinity for versican than aggrecan". J. Biol. Chem. 279 (13): 12060–6. doi:10.1074/jbc.M310091200. PMID 14724283.
• Kou I, Ikegawa S (2005). "SOX9-dependent and -independent transcriptional regulation of human cartilage link protein". J. Biol. Chem. 279 (49): 50942–8. doi:10.1074/jbc.M406786200. PMID 15456769.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.