Glucose-6-phosphate dehydrogenase deficiency classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

G6PD deficiency may be classified to into 5 subtypes and gives some approximation of the magnitude of hemolysis an individual may incur in the setting of an oxidative stress.

Classification

Glucose-6-phosphate dehydrogenase deficiency Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

Glucose-6-phosphate dehydrogenase deficiency classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Glucose-6-phosphate dehydrogenase deficiency classification

CDC on Glucose-6-phosphate dehydrogenase deficiency classification

Glucose-6-phosphate dehydrogenase deficiency classification in the news

Blogs on Glucose-6-phosphate dehydrogenase deficiency classification

Directions to Hospitals Treating Glucose-6-phosphate dehydrogenase deficiency

Risk calculators and risk factors for Glucose-6-phosphate dehydrogenase deficiency classification

G6PD deficiency may be classified according to World Health Organization into 5 subtypes: [1][2]

  • Class I: Severe deficiency (<10% activity) with chronic hemolytic anemia.
  • Class II: Severe deficiency (<10% activity), with intermittent hemolysis. G6PD Mediterranean deficiency is a class II deficiency.
  • Class III: Moderate deficiency (10-60% activity), hemolysis with significant oxidant stress. G6PD A- deficiency is a class III deficiency.
  • Class IV: No enzyme deficiency or hemolysis, no clinical sequelae. it has G6PD B, normal wild-type enzyme
  • Class V: Increased enzyme activity (more than twice normal), no clinical sequela

References

  1. "Glucose-6-phosphate dehydrogenase deficiency. WHO Working Group". Bull. World Health Organ. 67 (6): 601–11. 1989. PMC 2491315. PMID 2633878.
  2. Frank JE (October 2005). "Diagnosis and management of G6PD deficiency". Am Fam Physician. 72 (7): 1277–82. PMID 16225031.

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