Giant platelet disorder
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelet disorder occurs for inherited diseases like Bernard-Soulier syndrome, gray platelet syndrome and May-Hegglin anomaly.
Giant platelet disorders can be further categorized:
- caused by auto-immune disorders, i.e. Immune Thrombocytopenic Purpura (ITP) , characterized by low platelet count, but high MPV (Mean-Platelet Volume).
- Caused by glycoprotein abnormalities: Bernard-Soulier syndrome, Velocardiofacial syndrome
- Caused by calpain defect: Montreal platelet syndrome
- Caused by alpha granules defect: Gray platelet syndrome
- Characterized by abnormal neutrophil inclusions: May-Hegglin anomaly, Sebastian syndrome
- With systemic manifestations: Hereditary macrothrombocytopenia with hearing loss, Epstein syndrome, Fechtner syndrome
- With no specific abnormalities: Mediterranean macrothrombocytopenia
- Harris platelet syndrome
Signs and symptoms
- ↑ Mhawech, Paulette; Saleem, Abdus (2000). "Inherited Giant Platelet Disorders". American Journal of Clinical Pathology. 113 (2): 176–90. doi:10.1309/FC4H-LM5V-VCW8-DNJU. PMID 10664620.
- ↑ Platelet Disorders Overview of Platelet Disorders at eMedicine