Gallamine

	WikiDoc Resources for Gallamine
Articles
Most recent articles on Gallamine Most cited articles on Gallamine Review articles on Gallamine Articles on Gallamine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Gallamine Images of Gallamine Photos of Gallamine Podcasts & MP3s on Gallamine Videos on Gallamine
Evidence Based Medicine
Cochrane Collaboration on Gallamine Bandolier on Gallamine TRIP on Gallamine
Clinical Trials
Ongoing Trials on Gallamine at Clinical Trials.gov Trial results on Gallamine Clinical Trials on Gallamine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Gallamine NICE Guidance on Gallamine NHS PRODIGY Guidance FDA on Gallamine CDC on Gallamine
Books
Books on Gallamine
News
Gallamine in the news Be alerted to news on Gallamine News trends on Gallamine
Commentary
Blogs on Gallamine
Definitions
Definitions of Gallamine
Patient Resources / Community
Patient resources on Gallamine Discussion groups on Gallamine Patient Handouts on Gallamine Directions to Hospitals Treating Gallamine Risk calculators and risk factors for Gallamine
Healthcare Provider Resources
Symptoms of Gallamine Causes & Risk Factors for Gallamine Diagnostic studies for Gallamine Treatment of Gallamine
Continuing Medical Education (CME)
CME Programs on Gallamine
International
Gallamine en Espanol Gallamine en Francais
Business
Gallamine in the Marketplace Patents on Gallamine
Experimental / Informatics
List of terms related to Gallamine

Gallamine
Clinical data
Trade names	Flaxedil
AHFS/Drugs.com	International Drug Names
ATC code	M03AC02 (WHO) ;
Identifiers
	IUPAC name 2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide;
CAS Number	65-29-2 ;
PubChem CID	6172;
IUPHAR/BPS	356;
DrugBank	DB00483 ;
ChemSpider	5937 ;
UNII	Q3254X40X2;
KEGG	D02292 ;
ChEBI	CHEBI:503442 ;
ChEMBL	ChEMBL1200993 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C30H60N3O3+3 · 3 I− (gallamine triethiodide); C24H45N3O3 (gallamine)
Molar mass	891.529 g/mol (gallamine triethiodide); 423.633 g/mol; (gallamine)
3D model (JSmol)	Interactive image;
	SMILES [I-].[I-].[I-].O(c1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)CC[N+](CC)(CC)CC;
	InChI InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 ; Key:ICLWTJIMXVISSR-UHFFFAOYSA-N ;
(what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.^[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.^[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia^[3]^[4] and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.^[5]

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

↑ "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.
↑ "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
↑ Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German). 14 (10): 298–301. PMID 4380161. |access-date= requires |url= (help)
↑ WALTS LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology. 24: 119. doi:10.1097/00000542-196301000-00024. PMID 13998750. Retrieved 2014-09-20.
↑ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med. 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.