GC rich repressor elements
GC rich repressor element
Down regulation of smooth muscle myosin heavy chain (SM MHC) expression in cultured smooth muscle cells is associated with progressive methylation of a GC rich repressor element (GCGGGA) within the SM MHC promoter.[1]
Regular occurrences
Negative strand negative direction: 0,
Positive strand negative direction: 2, GCGGGA at 1682, GCGGGA at 4001,
Negative strand positive direction: 6, GCGGGA at 408, GCGGGA at 1592, GCGGGA at 1682, GCGGGA at 3672, GCGGGA at 4431, GCGGGA at 4441,
Positive strand positive direction: 5, GCGGGA at 454, GCGGGA at 1658, GCGGGA at 1674, GCGGGA at 1771, GCGGGA at 4293,
Complement occurrences
Negative strand negative direction: 2, CGCCCT at 1682, CGCCCT at 4001,
Positive strand negative direction: 0,
Negative strand positive direction: 5, CGCCCT at 454, CGCCCT at 1658, CGCCCT at 1674, CGCCCT at 1771, CGCCCT at 4293,
Positive strand positive direction: 6, CGCCCT at 408, CGCCCT at 1592, CGCCCT at 1682, CGCCCT at 3672, CGCCCT at 4431, CGCCCT at 4441,
Inverse occurrences
Negative strand negative direction: 0,
Positive strand negative direction: 0,
Negative strand positive direction: 1, AGGGCG at 1900,
Positive strand positive direction: 0,
Complement inverse occurrences
Negative strand negative direction: 0,
Positive strand negative direction: 0,
Negative strand positive direction: 0.
Positive strand positive direction: 1, TCCCGC at 1900.
References
1. Julian M Rozenberg, Daniel B Tesfu, Srilaxmi Musunuri, Joan M Taylor & Christopher P Mack (December 2014). DNA methylation of a GC repressor element in the smooth muscle myosin heavy chain promoter facilitates binding of the Notch-associated transcription factor RBPJ/CSL1. Arterioscler. Thromb. Vasc. Biol. 2014; 34(12):2624–2631. PMID: 25324571. doi:10.1161/ATVBAHA.114.304634. (Rozenberg et al. 2014)