GBGT1

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Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1 gene.^[1]^[2]^[3]

This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.^[3]

References

↑ Xu H, Storch T, Yu M, Elliott SP, Haslam DB (Nov 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". J Biol Chem. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200.
↑ Haslam DB, Baenziger JU (Nov 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proc Natl Acad Sci U S A. 93 (20): 10697–702. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242.
↑ ^3.0 ^3.1 "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[pmid10506200-1] Xu H, Storch T, Yu M, Elliott SP, Haslam DB (Nov 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". J Biol Chem. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200.

[pmid8855242-2] Haslam DB, Baenziger JU (Nov 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proc Natl Acad Sci U S A. 93 (20): 10697–702. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242.

[entrez-3] 3.0 ^3.1 "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1".

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[3]

GBGT1

References

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