Fatty liver causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:



Common Causes

Fatty liver is commonly associated with alcohol or metabolic syndrome (diabetes, hypertension and dyslipidemia) but can also be due to any one of many causes:[1][2]

Causes by Organ System

Cardiovascular Patent ductus venosus
Chemical / poisoning Alcohol, Carbon tetrachloride, Ethanol, Mushroom poisoning, Phosphorous
Dermatologic No underlying causes
Drug Side Effect Amiodarone, Anti retroviral therapy, Diltiazem, Febuxostat, Glucocorticoids, Lomitapide, Methotrexate, Tamoxifen, Tetracycline, Valproic acid, Mipomersen
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, Type II diabetes
Environmental No underlying causes
Gastroenterologic Autoimmune hepatitis, Inflammatory bowel disease, Jejunal diverticulosis with bacterial overgrowth, Non alcoholic steatohepatitis
Genetic 3-alpha-hydroxyacyl-CoA dehydrogenase deficiency, Abetalipoproteinaemia, Alpha1-antitrypsin deficiency, Chanarin-Dorfman disease, Citrullinemia type 2, Congenital generalized lipodystrophy type 1, Congenital generalized lipodystrophy type 2, Cystic fibrosis, Fructose-1, 6-diphosphatase deficiency, Long-chain acyl-CoA dehydrogenase deficiency, Medium chain acyl-CoA dehydrogenase deficiency, Neutral lipid storage disease with myopathy, Very long-chain acyl-CoA dehydrogenase deficiency, Wilson disease
Hematologic No underlying causes
Iatrogenic Gastric bypass, Jejunoileal bypass, Total parenteral nutrition
Infectious Disease Hepatitis C, HIV
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic Familial combined hyperlipidemia, Galactosemia, Glycogen storage disorders, Hypertriglyceridemia, Hypobetalipoproteinemia, Iron overload, Kwashiorkor, Lipodystrophy, Malnutrition, Refeeding syndrome, Tyrosinemia, Weber-Christian disease
Obstetric/Gynecologic Acute fatty liver of pregnancy
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Metabolic syndrome, Obesity, Overnutrition, Severe weight loss

Causes in Alphabetical Order


  1. Angulo P (2002). "Nonalcoholic fatty liver disease". N. Engl. J. Med. 346 (16): 1221–31. doi:10.1056/NEJMra011775. PMID 11961152.
  2. Bayard M, Holt J, Boroughs E (2006). "Nonalcoholic fatty liver disease". American family physician. 73 (11): 1961–8. PMID 16770927.