Fas associated factor family member 2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Fas associated factor family member 2 is a protein that in humans is encoded by the FAF2 gene.

Function

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008].

Further reading

• Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, Matsumoto K, Akasawa A, Saito H, Oshida T (October 2002). "Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients". Biochem. Biophys. Res. Commun. 297 (5): 1282–90. PMID 12372427.
• Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F (May 2010). "The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans". Mol. Cell. Biol. 30 (9): 2264–79. doi:10.1128/MCB.01450-08. PMC 2863595. PMID 20160012.
• Lee JN, Kim H, Yao H, Chen Y, Weng K, Ye J (December 2010). "Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis". Proc. Natl. Acad. Sci. U.S.A. 107 (50): 21424–9. doi:10.1073/pnas.1011859107. PMC 3003070. PMID 21115839.
• Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T (March 2012). "Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets". Mol. Biol. Cell. 23 (5): 800–10. doi:10.1091/mbc.E11-11-0950. PMC 3290640. PMID 22238364.
• Wang CW, Lee SC (June 2012). "The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis". J. Cell Sci. 125 (Pt 12): 2930–9. doi:10.1242/jcs.100230. PMID 22454508.
• Olzmann JA, Richter CM, Kopito RR (January 2013). "Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover". Proc. Natl. Acad. Sci. U.S.A. 110 (4): 1345–50. doi:10.1073/pnas.1213738110. PMC 3557085. PMID 23297223.
• Kim H, Zhang H, Meng D, Russell G, Lee JN, Ye J (August 2013). "UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids". J. Lipid Res. 54 (8): 2144–52. doi:10.1194/jlr.M037218. PMC 3708364. PMID 23720822.
• Kim H, Ye J (April 2014). "Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8". Curr. Opin. Lipidol. 25 (2): 118–24. doi:10.1097/MOL.0000000000000048. PMID 24378746.
• Schrul B, Kopito RR (July 2016). "Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains". Nat. Cell Biol. 18 (7): 740–51. doi:10.1038/ncb3373. PMC 4925261. PMID 27295553.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.