Fanconi anemia risk factors
|
Fanconi anemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fanconi anemia risk factors On the Web |
|
American Roentgen Ray Society Images of Fanconi anemia risk factors |
|
Risk calculators and risk factors for Fanconi anemia risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern.
Risk factors
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern, meaning that both parents must harbor the gene mutation to have an affected child. There are no other particular risk factors for Fanconi anemia. This is a genetic disorder that is caused by a mutation in genes involved in DNA damage response. Patients with Fanconi anemia are more susceptible to malignancy such as acute myeloid leukemia, and a risk factor for development of malignancies includes exposure to radiation and carcinogens.[1]
References
- ↑ Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI (2013). "The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma". Mutat Res. 743-744: 78–88. doi:10.1016/j.mrfmmm.2013.01.001. PMC 3661751. PMID 23333482.