FARSA (gene)

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.[1][2]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression[2]

References

  1. Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.
  2. 2.0 2.1 "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".

Further reading