Ethacizine

Ethacizine

Clinical data
Trade names	Ethacizin
AHFS/Drugs.com	International Drug Names
ATC code	C01BC09 (WHO)
Legal status
Legal status	Prescription only (RU)
Pharmacokinetic data
Bioavailability	~40% (oral)
Protein binding	90%
Metabolism	Extensive hepatic
Elimination half-life	2.5 hours
Identifiers
IUPAC name ethyl N-[10-[3-(diethylamino)propanoyl]phenothiazin-2-yl]carbamate
CAS Number	33414-33-4 Y
PubChem CID	107841
ChemSpider	96982 Y
UNII	FE5SPV1Z6G
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H27N3O3S
Molar mass	413.54 g/mol
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCC(=O)N1C2=CC=CC=C2SC3=C1C=C(C=C3)NC(=O)OCC
InChI InChI=1S/C22H27N3O3S/c1-4-24(5-2)14-13-21(26)25-17-9-7-8-10-19(17)29-20-12-11-16(15-18(20)25)23-22(27)28-6-3/h7-12,15H,4-6,13-14H2,1-3H3,(H,23,27) Y Key:PQXGNJKJMFUPPM-UHFFFAOYSA-N Y

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Definitions
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. It is also indicated as a treatment of refractory tachycardia associated with Wolff–Parkinson–White syndrome.

It is manufactured under the brand name Ethacizin (Этацизин) by Olainfarm.