Esthesioneuroblastoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Based on the duration of symptoms, esthesioneuroblastoma may be classified into two subtypes: neuroblastoma proper and neuroendocrine carcinomas.[1]
Classification
- Neuroblastoma proper
- Neuroblastoma proper has a histologic presentation similar to that of peripheral neuroblastomas of childhood.
- Esthesioneuroblastoma is composed of sheets of poorly demarcated groups of cells separated by fine connective tissue trabeculae.
- The cells are small and typically show no mitotic activity between the cells.
- Rosettes of the Homer-Wright type are present.
- On electronic microscopy, there is the presence of a dendritic cytoplasmic process with accumulations of small core granules within the process.
- Neuroblastomas proper contain fibrillary material.
- Neuroendocrine carcinomas
- Neuroendocrine carcinoma is admixture with glands.
- A neurofibrillary component is absent and the growth pattern is that of solid nests without rosettes.
- Dense core granules similar to those of neuroblastomas are present in the cytoplasm and cytoplasmic extensions.
References
- ↑ Min KW (1995). "Usefulness of electron microscopy in the diagnosis of "small" round cell tumors of the sinonasal region". Ultrastruct Pathol. 19 (5): 347–63. PMID 7483011.