Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family
Identifiers
Symbol	Exo_endo_phos
Pfam	PF03372
InterPro	IPR005135
PROSITE	PDOC00598
SCOP	1ako
SUPERFAMILY	1ako
OPM superfamily	148
OPM protein	1zwx
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling .

Examples

• AP endonuclease proteins EC 4.2.99.18,
• DNase I proteins EC 3.1.21.1,
• Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC 3.1.3.56
• Sphingomyelinase EC 3.1.4.12 and Nocturnin O35710.

Subfamilies

• Inositol polyphosphate related phosphatase InterPro: IPR000300

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP;

References

• [1]. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M; Trends Biochem Sci 2000;25:272-273. PMID 10838565
• [2]. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; Nature 1995;374:381-386. PMID 7885481
• [3]. DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D; J Mol Biol 1991;222:645-667. PMID 1748997