Donor lymphocyte infusion
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Overview
Donor lymphocyte infusion (DLI) is a form of adoptive immunotherapy used after hematopoietic stem cell transplantation. Lymphocytes from the original stem cell donor are infused, after the transplant, to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted.[1][2] Complications of DLI include acute and chronic graft-versus-host disease and bone marrow aplasia, resulting in immunosuppression and susceptibility to opportunistic infections.[3]
Notes
- ↑ Porter D, Levine JE (2006). "Graft-versus-host disease and graft-versus-leukemia after donor leukocyte infusion". Semin. Hematol. 43 (1): 53–61. doi:10.1053/j.seminhematol.2005.09.005. PMID 16412789.
- ↑ Loren AW, Porter DL (2006). "Donor leukocyte infusions after unrelated donor hematopoietic stem cell transplantation". Current opinion in oncology. 18 (2): 107–14. doi:10.1097/01.cco.0000208781.61452.d3. PMID 16462177.
- ↑ Luznik L, Fuchs EJ (2002). "Donor lymphocyte infusions to treat hematologic malignancies in relapse after allogeneic blood or marrow transplantation". Cancer control : journal of the Moffitt Cancer Center. 9 (2): 123–37. PMID 11965233.Full text
References
- Thomas' Hematopoietic Cell Transplantation, ed. Blume KG, Forman SJ, Appelbaum FR. Blackwell Publishers, Cambridge, MA: 2004. ISBN 1-4051-1256-5.