|F5/8 type C domain|
Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major domain of many blood coagulation factors.
Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain). In the Dictyostelium discoideum (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells. The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity. It forms an amphipathic alpha-helix, which binds to the membrane. FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulfide bond. A further disulfide bond is located near the C-terminal of the second FA58C domain in MFGM Q08431.
Human proteins containing this domain
AEBP1; BTBD9; CASPR4; CNTNAP1; CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; CPXM1; CPXM2; DCBLD1; DCBLD2; DDR1; DDR2; EDIL3; F5; F8; F8B; MFGE8; NRP1; NRP2; RS1; SSPO;
- ↑ Davie EW, Kane WH (1986). "Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin". 83 (18): 6800–6804. PMID 3092220. Unknown parameter
|jour nal=ignored (help)
- ↑ Rutter WJ, Edman JC, Johnson JD (1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5677–5681. PMID 8390675.
- ↑ Couto JR, Taylor MR, Godwin SG, Ceriani RL, Peterson JA (1996). "Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain". DNA Cell Biol. 15 (4): 281–286. PMID [//www.ncbi.nlm.nih.gov/pubmed/8
|pmid=value (help). line feed character in
|pmid=at position 2 (help)
- ↑ Davie EW, Kane WH (1988). "Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders". Blood. 71 (3): 539–555. PMID 3125864.
- ↑ Foster PA, Fulcher CA, Houghten RA, Zimmerman TS (1990). "Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine". Blood. 75 (10): 1999–2004. PMID 2110840.
- ↑ Kane WH, Peterson JA, Ortel TL, Quinn-Allen MA, Keller FG, Larocca D (1994). "Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras". J. Biol. Chem. 269 (22): 15898–15905. PMID 7515064.
- ↑ Baleja JD, Gilbert GE (1995). "Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as determined by NMR spectroscopy". Biochemistry. 34 (9): 3022–3031. PMID 7893714.
- ↑ Mann KG, Xue J, Kalafatis M (1993). "Determination of the disulfide bridges in factor Va light chain". Biochemistry. 32 (22): 5917–5923. PMID 8504111.
- ↑ Fujikawa K, McMullen BA, Davie EW, Hedner U, Ezban M (1995). "Locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A)". Protein Sci. 4 (4): 740–746. PMID 7613471.
- ↑ 10.0 10.1 Petersen TE, Hvarregaard J, AndersenMH, Berglund L, Rasmussen JT (1996). "Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules". Eur. J. Biochem. 240 (3): 628–636. PMID 8856064.
The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction. Baumgartner S, Hofmann K, Chiquet-Ehrismann R, Bucher P; Protein Sci 1998;7:1626-1631. PMID 9684896