Dexoxadrol

Dexoxadrol
	File:Dioxadrol.svg
Gene therapy
Clinical data
Physiological data
Legal status
Legal status	In general: legal;
Pharmacokinetic data
Identifiers
	IUPAC name (2S)-2-[(4S)-2,2-di(phenyl)-1,3-dioxolan-4-yl]piperidine;
CAS Number	6495-46-1;
PubChem Template:Abbreviation	3034023;
Chemical and physical data
Formula	C20H23NO2
Molar mass	309.40 g/mol

Dexoxadrol (Dioxadrol) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations.^[1]^[2]

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References

↑ Sax M, Wunsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Current Topics in Medicinal Chemistry. 2006;6(7):723-32.
↑ Aepkers M, Wunsch B. Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. Bioorganic and Medicinal Chemistry. 2005 Dec 15;13(24):6836-49.

Template:Dissociative hallucinogens

[1] Sax M, Wunsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Current Topics in Medicinal Chemistry. 2006;6(7):723-32.

[2] Aepkers M, Wunsch B. Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. Bioorganic and Medicinal Chemistry. 2005 Dec 15;13(24):6836-49.

[1]

[2]

Dexoxadrol

References

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