Detoxication

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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
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Commentary
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Healthcare Provider Resources
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Business
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Experimental / Informatics
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The major metabolites formed from most drug metabolism are detoxication products. There are two common patterns observed:

1. A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (e.g., Pentobarbital and Hydroxypentobarbital)
2. A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity.

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