Beta-defensin 105 is a protein that is encoded by the DEFB105Agene in humans.[1][2][3]
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[3]
Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract". Physiol. Genomics. 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID16033865.
Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID15727258.
Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice". J. Immunol. 169 (5): 2516–23. doi:10.4049/jimmunol.169.5.2516. PMID12193721.
