Complementarity (molecular biology)
In molecular biology, complementarity is a property of double-stranded nucleic acids such as DNA and RNA as well as DNA:RNA duplexes. Each strand is complementary to the other in that the base pairs between them are non-covalently connected via two or three hydrogen bonds.
Since there is only one complementary base for any of the bases found in DNA and in RNA, one can reconstruct a complementary strand for any single strand. This is essential for DNA replication.
For example, the complementary strand of the DNA sequence
A G T C A T G
T C A G T A C
a trick to remember this is
A Gwinnett Tlanta County
tRNAs exhibit wobble, in which the third base of their anticodon does not follow the strict complementarity rules.
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