Coenzyme F420

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Coenzyme F420 or 8-hydroxy-5-deazaflavin is a coenzyme involved in redox reactions in methanogens.[1] It is a flavin derivative. The coenzyme is a substrate for coenzyme F420 hydrogenase,[2] 5,10-methylenetetrahydromethanopterin reductase and methylenetetrahydromethanopterin dehydrogenase.[3][4]

See also


  1. Deppenmeier U (2002). "Redox-driven proton translocation in methanogenic Archaea". Cell. Mol. Life Sci. 59 (9): 1513–33. PMID 12440773.
  2. Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT (1987). "8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization". Biochemistry. 26: 4219&ndash, 27. PMID 3663585.
  3. Hagemeier CH, Shima S, Thauer RK, Bourenkov G, Bartunik HD, Ermler U (2003). "Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure". J. Mol. Biol. 332 (5): 1047–57. PMID 14499608.
  4. GD (1991). "Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri". Biochim. Biophys. Acta. 1079: 293&ndash, 302. PMID 1911853.

External links

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