Bone or cartilage mass biopsy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Bone biopsy findings associated with bone and cartilage tumors will depend on tumor histology, common findings include: anastomosing bony trabeculae, calcifications surrounded by cells nests, and increased/decreased osteoblasts and osteoclasts.[1]
Biopsy
Common types of bone biopsy, include:[1][2]
- Open
- Performed during surgery
- Diagnostic accuracy is similar to closed biopsy.
- On malignant lesions, biopsy incisions are: longitudinal, small, or anatomically placed to minimize contamination of normal tissue
- Increased risk of complications
- Tissue biopsy analyzed for bacterial and fungal culture, because bone infections may mimic a bone tumor
- Closed
- Initial biopsy in most bone and cartilage tumors.
- Less invasive and lower risk of tissue contamination with tumor cells
- Usually involves CT image-guided percutaneous biopsy
- Less risk of complications
- Biopsy in tumors that are predominantly cystic or with fluid levels (likely to result in nondiagnostic results)
- Less painful, and less costly
- Disadvantages, include: insufficient tissue from lesions and erroneous diagnosis of tumor grade
- Common bone and cartilage tumors biopsy findings, include:
- Anastomosing bony trabeculae
- Calcifications surrounded by cells nests
- Increased/decreased osteoblasts and osteoclasts
References
- ↑ 1.0 1.1 Mankin HJ, Lange TA, Spanier SS (2006). "THE CLASSIC: The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors. The Journal of Bone and Joint Surgery, 1982;64:1121-1127". Clin. Orthop. Relat. Res. 450: 4–10. doi:10.1097/01.blo.0000229299.36969.b5. PMID 16951637.
- ↑ Jelinek JS, Murphey MD, Welker JA, Henshaw RM, Kransdorf MJ, Shmookler BM, Malawer MM (2002). "Diagnosis of primary bone tumors with image-guided percutaneous biopsy: experience with 110 tumors". Radiology. 223 (3): 731–7. doi:10.1148/radiol.2233011050. PMID 12034942.