Bepridil

Bepridil
Clinical data
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	Oral
ATC code	C08EA02 (WHO) ;
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	99%
Metabolism	Hepatic, CYP3A4-mediated
Elimination half-life	42 hours
Excretion	Renal
Identifiers
	IUPAC name (±)-(beta)-[(2-Methylpropoxy)methyl]-N-phenyl- N -(phenyl- methyl)-1-pyrrolidineethanamine;
CAS Number	64706-54-3;
PubChem CID	2351;
DrugBank	APRD00727;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C24H34N2O
Molar mass	421.02 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bepridil (trade name Vascor) is a calcium channel blocker once used to treat angina. It is no longer sold in the United States.

It is nonselective.^[1]

It has been discussed as a possible option in the treatment of atrial fibrillation.^[2]

It has been implicated in causing ventricular arrhythmia (Torsade de pointes).

Clinical data

Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	C08EA02 (WHO)
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	99%
Metabolism	Hepatic, CYP3A4-mediated
Elimination half-life	42 hours
Excretion	Renal
Identifiers
IUPAC name (±)-(beta)-[(2-Methylpropoxy)methyl]-N-phenyl- N -(phenyl- methyl)-1-pyrrolidineethanamine
CAS Number	64706-54-3
PubChem CID	2351
DrugBank	APRD00727
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₄H₃₄N₂O
Molar mass	421.02 g/mol