Bedwetting medical therapy

Jump to navigation Jump to search

Bedwetting Microchapters


Patient Information



Historical Perspective




Differentiating Bedwetting from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings

X Ray


Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Bedwetting medical therapy On the Web

recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Bedwetting medical therapy

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

National Guidelines Clearinghouse

NICE Guidance

FDA on Bedwetting medical therapy

CDC on Bedwetting medical therapy

Bedwetting medical therapy in the news

Blogs on Bedwetting medical therapy

Directions to Hospitals Treating Bedwetting

Risk calculators and risk factors for Bedwetting medical therapy

Editor(s)-in-Chief: C. Michael Gibson, M.S.,M.D. [1] Phone:617-632-7753; Steven C. Campbell, M.D., Ph.D., [2] Phone:216-444-5595 Professor of Surgery, Residency Program Director, Section of Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic.


Treatments range from behavioral-based options such as bedwetting alarms, to medication such as hormone replacement, and even surgery such as urethral enlargement. Since most bedwetting is simply a developmental delay, most treatment plans aim to protect or improve self-esteem.[1] Bedwetting children and adults can suffer emotional stress or psychological injury if they feel shamed by the condition. Treatment guidelines recommend that the physician counsel the parents, warning about psychological damage caused by pressure, shaming, or punishment for a condition children cannot control.[1]

Medical Therapy

There are a number of treatment and condition management options for bedwetting. The following options apply when the bedwetting is not caused by a specifically identifiable medical condition such as a bladder abnormality or diabetes.

When Treatment is Recommended

Doctors consider treatment when there is a specific medical condition such as bladder abnormalities, infection, or diabetes. Physicians also treat bedwetting when it may harm the child's self-esteem or relationships with family/friends. Only a small percentage of bedwetting is caused by a specific medical condition, so most treatment is prompted by concern for the child's emotional welfare. Behavioral treatment of bedwetting overall tends to show increased self-esteem for children [2] Parents become concerned much earlier than doctors. A study in 1980 asked parents and physicians the age that children should stay dry at night. The average parent response was 2.75 years old, while the average physician response was 5.13 years old.[3] Punishment is not effective and can interfere with treatment.

Treatment Options with High Success Rates


Almost all children will outgrow bedwetting. For this reason, urologists and pediatricians frequently recommend delaying treatment until the child is at least six or seven years old. Physicians may begin treatment earlier if they perceive the condition is damaging the child's self-esteem and/or relationships with family/friends.

Bedwetting Alarms

Physicians also frequently suggest bedwetting alarms which sound a loud tone when they sense moisture. This can help condition the child to wake at the sensation of a full bladder. These alarms are considered effective, with study participants being 13 times more likely to become dry at night. There is a 29% to 69% relapse rate, however, so the treatment may need to be repeated.[4]

DDAVP (Desmopressin)

Desmopressin tablets are a synthetic replacement for antidiuretic hormone, the hormone that reduces urine production during sleep. Desmopressin is usually used in the form of desmopressin acetate, DDAVP. Patients taking DDAVP are 4.5 times more likely to stay dry than those taking a placebo.[4] The drug replaces the hormone for that night with no cumulative effect.
US drug regulators have banned using desmopressin nasal sprays for treating bedwetting since the oral format are considered safer.

Tricyclic Antidepressants

Tricyclic antidepressant prescription drugs with anti-muscarinic properties have been proven successful in treating bedwetting, but also have an increased risk of side effects, including death from overdose.[5] These drugs include amitriptyline, imipramine and nortriptyline. Studies find that patients using these drugs are 4.2 times as likely to stay dry as those taking a placebo.[4] The relapse rates after stopping the medicines are close to 50%.

Condition Management Options

Absorbent Underwear

Absorbent underwear or diapers can reduce embarrassment for bedwetters and make cleanup easier for caregivers. These products are known as training pants or diapers when used for younger children, and as absorbent underwear or incontinence briefs when marketed for older children and adults. Some brands of diaper are marketed especially for sufferers of bedwetting. A major benefit is the reduced stress on both the bedwetter and caregivers. Absorbent underwear can be especially beneficial for bedwetting children wishing to attend sleepovers or campouts, reducing emotional problems caused by social isolation and/or embarrassment in front of peers. Extended diaper usage may interfere with learning to stay dry at night, at least in adults with severe disabilities.[6]

  • Waterproof mattress pads are used in some cases to ease clean-up of bedwetting incidents, however they only protect the mattress, and the sheets, bedding or sleeping partner may be soiled.

Unproven/Ineffective Treatment Options


While acupuncture is safe in most adolescents,[7] studies done to assess its effectiveness for nocturnal enuresis are of low quality.[8]

Dry Bed Training

Dry bed training consists of a strict schedule of waking the child at night, attempting to condition the child into waking by himself/herself.[9] Studies show this training is ineffective by itself[10] and does not increase the success rate when used in conjunction with a bedwetting alarm.[4]

Star Chart

A star chart allows a child and parents to track dry nights, as a record and/or as part of a reward program. This can be done either alone or with other treatments. There is no research to show effectiveness, either in reducing bedwetting or in helping self-esteem.[4] Some psychologists, however, recommend star charts as a way to celebrate successes and help a child's self-esteem.[9]


  1. 1.0 1.1
  2. Patrick C. Friman and Kevin M. Jones (2005): Behavioral Treatment for Nocturnal Enuresis. Journal of Early and Intensive Behavioral Intervention 2 (4), Pg. 259- 267 BAO
  3. Shelov SP, Gundy J, Weiss JC; et al. (1981). "Enuresis: a contrast of attitudes of parents and physicians". Pediatrics. 67 (5): 707–10. PMID 7255000. Unknown parameter |month= ignored (help)
  4. 4.0 4.1 4.2 4.3 4.4 Evans, Jonathan. "Evidence based paediatrics: Evidence based management of nocturnal enuresis". BMJ. Retrieved 2008-02-03.
  5. Evaluation and management of enuresis, W. Lane M. Robinson, N Engl J Med, 360:1429
  7. Jindal, Vanita. "Safety and efficacy of acupuncture in children: A review of the evidence". Journal of Pediatric Hemotol Oncology. 30 (6): 431–442. doi:10.1097/MPH.0b013e318165b2cc. Retrieved 2012-02-18. Unknown parameter |coauthors= ignored (help)
  8. Tang, J.; Yeung, C. (2005), "Acupuncture for nocturnal enuresis in children: A systematic review and exploration of rationale", Neurourol. Urodyn, 24 (267): 272, doi:10.1002/nau.20108
  9. 9.0 9.1 Fackler, Amy. "Dry-bed training for bed-wetting". Yahoo! Health. Retrieved 2008-02-03.
  10. "Clinical Evidence Concise: Nocturnal Enuresis". American Family Physician. Retrieved 2008-02-03.

Template:WikiDoc Sources