BCCIP

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

BRCA2 and CDKN1A-interacting protein is a protein that in humans is encoded by the BCCIP gene.

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.

Interactions

BCCIP has been shown to interact with BRCA2, P21, and PTPmu (PTPRM)

External links

• Human BCCIP genome location and BCCIP gene details page in the UCSC Genome Browser.

Further reading

• Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992). "2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes". Biochim. Biophys. Acta. 1125 (2): 203–9. doi:10.1016/0005-2760(92)90046-X. PMID 1571364.
• Machackova E, Damborsky J, Valik D, Foretova L (2002). "Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic". Hum. Mutat. 18 (6): 545. doi:10.1002/humu.1232. PMID 11748848.
• Armakolas A, Ladopoulou A, Konstantopoulou I, et al. (2002). "BRCA2 gene mutations in Greek patients with familial breast cancer". Hum. Mutat. 19 (1): 81–2. doi:10.1002/humu.9003. PMID 11754111.
• Robson M, Scheuer L, Nafa K, et al. (2002). "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer". J. Med. Genet. 39 (2): 126–8. doi:10.1136/jmg.39.2.126. PMC 1735025. PMID 11836363.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene. 302 (1–2): 139–46. doi:10.1016/S0378-1119(02)01098-3. PMID 12527204.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Meng X, Liu J, Shen Z (2004). "Inhibition of G1 to S cell cycle progression by BCCIP beta". Cell Cycle. 3 (3): 343–8. doi:10.4161/cc.3.3.672. PMID 14726710.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Meng X, Lu H, Shen Z (2007). "BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1". Cell Cycle. 3 (11): 1457–62. doi:10.4161/cc.3.11.1213. PMID 15539944.
• Lu H, Guo X, Meng X, et al. (2005). "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair". Mol. Cell. Biol. 25 (5): 1949–57. doi:10.1128/MCB.25.5.1949-1957.2005. PMC 549367. PMID 15713648.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Meng X, Yue J, Liu Z, Shen Z (2007). "Abrogation of the transactivation activity of p53 by BCCIP down-regulation". J. Biol. Chem. 282 (3): 1570–6. doi:10.1074/jbc.M607520200. PMC 2679999. PMID 17135243.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.