Autoimmune hepatitis Diagnostic Study of Choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]

Overview

Diagnostic Study of Choice

Gold standard/Study of choice:

  • Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis
  • Liver biopsy is performed by following methods:
    • Percutaneous liver biopsy with or without ultrasound guidance
    • Transjugular liver biopsy

Histology findings usually found on biopsy:

  • Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark
    • There is lymphoplasmacytic periportal infiltrate which invade the limiting plate
    • There is an abundance of plasma cells and eosinophils are usually present
    • Portal lesion spares the biliary tree
  • A plasma cell infiltrate lead to plasma cell hepatitis
  • Bridging necrosis
  • Fibrosis


Fibrosis is present in most patients with autoimmune hepatitis. Without effective therapy, fibrosis starts to connect the portal and central areas, which ultimately leads to cirrhosis.

References

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