Aphthous ulcer historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: José Eduardo Riceto Loyola Junior, M.D.[2]

Overview

• The term aphthae was first used by Hippocrates at between 460-370 B.C., in relation to disorders of the mouth.

Historical perspective

• The term aphthae was first used by Hippocrates at between 460-370 B.C., in relation to disorders of the mouth.
• In 1898, the first clinical description of the aphthous stomatitis was reported by Von Mikulicz and Kumme as a Mikuliez aphthea
• In 1911, stomatitis aphthae recurrens cicatricicans was first described by Sutton.
• In 1961, stomatitis aphthae recurrens herpetiformis was first described by Cooke.