Amyotrophic lateral sclerosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Approximately 5-10% of cases of ALS are familial ALS. More than 25 different genes could be linked to the causation of familial ALS. However, the remaining majority 90-95% of ALS cases are Sporadic ALS. There is no known cause for Sporadic ALS.

Cause

Approximately 5-10% of Familial ALS cases could be linked to different genes and their pathological pathways. More than 25 different genes mutations are attributed to Familial ALS. The most common ones include:

[1]

References

  1. Källstig E, McCabe BD, Schneider BL (2021). "The Links between ALS and NF-κB". Int J Mol Sci. 22 (8). doi:10.3390/ijms22083875. PMC 8070122 Check |pmc= value (help). PMID 33918092 PMID: 33918092 Check |pmid= value (help).

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