Amyotrophic lateral sclerosis causes
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Differentiating Amyotrophic lateral sclerosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Approximately 5-10% of cases of ALS are familial ALS. More than 25 different genes could be linked to the causation of familial ALS. However, the remaining majority 90-95% of ALS cases are Sporadic ALS. There is no known cause for Sporadic ALS.
Cause
Approximately 5-10% of Familial ALS cases could be linked to different genes and their pathological pathways. More than 25 different genes mutations are attributed to Familial ALS. The most common ones include:
- Chromosome 9 Open Reading Frame 72(c9orf72)
- TAR DNA-binding protein 43 (TDP-43)
- Fused in Sarcoma (FUS)
- Superoxide Dismutase 1 (SOD1)
- TANK-binding kinase 1 (TBK1)
- Optineurin (OPTN)
References
- ↑ Källstig E, McCabe BD, Schneider BL (2021). "The Links between ALS and NF-κB". Int J Mol Sci. 22 (8). doi:10.3390/ijms22083875. PMC 8070122 Check
|pmc=value (help). PMID 33918092 PMID: 33918092 Check|pmid=value (help).