Amanullin

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Template:Chembox E numberTemplate:Chembox AppearanceTemplate:Chembox SolubilityInWaterTemplate:Chembox Solubility

Amanullin

File:Amanullin structure.png
File:Amanullin 3 dimensional.png
Names
Other names 3-Isoleucine-alpha-amanitin
Identifiers
CAS Number	21803-57-6
3D model (JSmol)	Interactive image
ECHA InfoCard
PubChem CID	114856
SMILES O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(N)=O)C(N5[C@H]4C[C@@H](O)C5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC([C@@]([C@@H](C)CC)([H])N[C@@]4=O)=O
Properties
Chemical formula	C39H54N10O12S
Molar mass	886.86 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral Template:LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.

Toxicology

Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).

See also

• Mushroom poisoning

External links

• Amatoxins REVISED
• Poisonous Mushrooms (German)