Achlorhydria causes

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Achlorhydria Microchapters


Patient Information


Historical Perspective




Differentiating Achlorhydria from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings

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Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Luke Rusowicz-Orazem, B.S.


Achlorhydria is caused by intrinsic and extrinsic changes in the gastrointestinal system, including uptake of antibodies and bacterial infection. Less commonly, it can be caused by cancer, a life-threatening cause requiring prompt diagnosis and treatment.


Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect H2-receptor antagonists, Parietal cell antibodies, Proton pump inhibitors
Ear Nose Throat No underlying causes
Endocrine Mucolipidosis , Vipomas
Environmental No underlying causes
Gastroenterologic Atrophic gastritis, Gastric intrinsic factor antibodies, Menetrier disease, Somatostatinoma, Stomach cancer
Genetic No underlying causes
Hematologic Pernicious anemia
Iatrogenic Radiation therapy 
Infectious Disease Helicobacter pylori infection
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Somatostatinoma, Stomach cancer, Vipomas
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Autoimmune disorders , Gastric intrinsic factor antibodies
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order


  1. El-Omar EM, Oien K, El-Nujumi A; et al. (1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15–24. PMID 9207257.

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