ARID4B

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[1][2]

Function

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[2]

References

  1. Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
  2. 2.0 2.1 "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".

External links

Further reading