ALD-52

ALD-52

File:ALD-52 image.svg
Clinical data
Synonyms	ALD, N-acetyl-LSD, Acetyl lysergic acid diethylamide, d-acetyl lysergic acid diethylamide, d-acetyldiethyllysergamide
Routes of administration	Oral
Legal status
Legal status	Analogue of LSD and therefore controlled in the US via the Federal Analog Act
Pharmacokinetic data
Metabolism	hepatic
Excretion	renal
Identifiers
IUPAC name 1-Acetyl-N,N-diethyllysergamide
CAS Number	3270-02-8
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H27N3O2
Molar mass	365.469 g/mol

ALD-52 or N-acetyl-LSD, is a chemical analogue of LSD (Lysergic Acid Diethylamide). It was originally discovered by Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.

Effects

In TiHKAL, Shulgin touches briefly on ALD-52 in entry 26, LSD. His writings are vague, second hand accounts, saying doses in the 50-175µg range have resulted in various conclusions. One found that there was less visual distortion than with LSD and it seems to produce less anxiety and was somewhat less potent than LSD. Another report claimed it was more effective in increasing blood pressure. Yet another could not tell them apart.

It has the same characteristics as LSD, but supposedly "without the anxiety, tenseness, and other problems inherent to it".

Dangers

In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 (D,L-Acetyllysergic acid diethylamide) is listed as having a lower (approximately ¹/₅) intravenous toxicity (in rabbits), a lower (approximately ¹/₈) pyretogenic effect, an equal psychological effect in man, and double the antiserotonin effect as compared with LSD.

History

It is possible ALD-52 was the active chemical in the "Orange Sunshine" LSD that was widely available in California through 1968 and 1969. The Sonoma County underground chemistry lab of Tim Scully and Nicholas Sand was the source for "Orange Sunshine." It was shut down by the police, and Scully was arrested and prosecuted. This resulted in the first drug analogue trial, where Scully claimed that he and his partners did nothing wrong, because they were producing ALD-52 which was not an illicit drug. However, as the prosecution claimed, there were problems with such a rationale: first, ALD-52 readily undergoes hydrolysis to LSD, and second, the synthesis of ALD-52 required LSD (this was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.

Sources

• Entry #26 from TiHKAL
• everything2
• Totse
• Lycaeum
• White Light