AKAP7

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.

External links

• Human AKAP7 genome location and AKAP7 gene details page in the UCSC Genome Browser.

Further reading

• Gold MG, Smith FD, Scott JD, Barford D (Feb 2008). "AKAP18 contains a phosphoesterase domain that binds AMP". Journal of Molecular Biology. 375 (5): 1329–1343. doi:10.1016/j.jmb.2007.11.037. PMC 3188456. PMID 18082768.
• Bengrine A, Li J, Awayda MS (Apr 2007). "The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel". FASEB Journal. 21 (4): 1189–1201. doi:10.1096/fj.06-6046com. PMID 17244820.
• Brown RL, August SL, Williams CJ, Moss SB (Jun 2003). "AKAP7gamma is a nuclear RI-binding AKAP". Biochemical and Biophysical Research Communications. 306 (2): 394–401. doi:10.1016/S0006-291X(03)00982-3. PMID 12804576.
• Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4445–4450. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
• Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL (Dec 1999). "Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms". The Journal of Cell Biology. 147 (7): 1481–1492. doi:10.1083/jcb.147.7.1481. PMC 2174236. PMID 10613906.