Zygomycosis pathophysiology: Difference between revisions

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Latest revision as of 19:33, 18 September 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The clinical hallmark of Zygomycosis is vascular invasion resulting in thrombosis and tissue infarction/necrosis.

References

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 ==Overview==
-Zygomycosis usually is a disease of the skin, but can also occur in the sinuses or gastrointestinal tract. In humans it is most prevalent in immunocompromised patients ([[AIDS|HIV/AIDS]], the [[old age|elderly]], [[Severe combined immunodeficiency|SCID]], etc) and patients in acidosis (diabetes, burns), particularly after barrier injury to the skin or mucus membranes.  Zygomycosis caused by ''Mucorales'' causes a rapidly progressing disease of sudden onset in sick or [[immunodeficiency|immunocompromised]] animals.  ''Entomophthorales'' cause chronic, local infections in otherwise healthy animals.  The important species that cause '''entomophthoromycosis''' are ''Conidiobolus coronatus'', ''C. incongruous'', and ''[[Basidiobolus ranarum]]''.  ''Conidiobolus'' infections of the upper respiratory system have been reported in humans, sheep, horses, and dogs, and ''Basidiobolus'' has been reported less commonly in humans and dogs.<ref name=Greene>{{cite journal |author=Greene C, Brockus C, Currin M, Jones C |title=Infection with Basidiobolus ranarum in two dogs |journal=J Am Vet Med Assoc |volume=221 |issue=4 |pages=528-32, 500 |year=2002 |id=PMID 12184703}}</ref>  Horses are one of the most common domestic animals to be affected by entomophthoromycosis.  ''C. coronatus'' causes lesions in the nasal and oral [[mucous membrane|mucosa]] of horses that may cause nasal discharge or difficulty breathing.  ''B. ranarum'' causes large circular nodules on the upper body and neck of horses.<ref>{{cite web | title = Zygomycosis | work = The Merck Veterinary Manual | date = 2006 | url = http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/51118.htm | accessdate = 2007-02-03 }}</ref>  ''Entomophthorales'' is found in soil and decaying plant matter, and specifically ''Basidiobolus'' can be contracted from insects and the feces of reptiles or amphibians.
+The clinical hallmark of Zygomycosis is [[vascular]] invasion resulting in [[thrombosis]] and tissue [[infarction]]/[[necrosis]].
-Zygomycosis of the sinuses can extend from the sinuses into the orbit and the cranial vault, leading to rhinocerebral mucormycosis.
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Zygomycosis pathophysiology: Difference between revisions

Latest revision as of 19:33, 18 September 2017

Overview

References

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