Wild-type (senile) amyloidosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
History
- The clinical features of wild-type (senile) amyloidosis depend on the type of organ or organ system involved.
- Wild-type (senile) amyloidosis, classified as systemic amyloidosis, can involve any organ in the body.
- Cardiac and peripheral nerves involvement can result in clinically evident pathology.[1]
- The most commonly involved organ is the heart and majority of the patients present with signs and symptoms of heart failure.[2]
Common Symptoms
- Patients suffering from heart failure secondary to wild-type (senile) amyloidosis can present with:[2]
- Arrhythmias with associated symptoms, such as palpitations
- Syncope and presyncope
- Syncope on exertion is an ominous sign of cardiac amyloidosis, as these patients cannot augment their cardiac output due to poor filling of the ventricle (restrictive cardiomyopathy).[4]
- Postural hypotension may be observed in patients with subendothelial amyloid deposition.[5]
- Chest pain or chest discomfort [6][7]
- Non-specific symptoms such as:
Less Common Symptoms
- Less common symptoms correspond to the involvement of organs or organ systems other than the heart. These can include:
References
- ↑ Ilia G. Halatchev, Jingsheng Zheng & Jiafu Ou (2018). "Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), previously known as senile cardiac amyloidosis: clinical presentation, diagnosis, management and emerging therapies". Journal of thoracic disease. 10 (3): 2034–2045. doi:10.21037/jtd.2018.03.134. PMID 29707360. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Belinda Ng, Lawreen H. Connors, Ravin Davidoff, Martha Skinner & Rodney H. Falk (2005). "Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis". Archives of internal medicine. 165 (12): 1425–1429. doi:10.1001/archinte.165.12.1425. PMID 15983293. Unknown parameter
|month=ignored (help) - ↑ Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Mugnai G, Cicoira M, Rossi A, Vassanelli C (2011). "Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report". Experimental and Clinical Cardiology. 16 (2): 51–3. PMC 3126684. PMID 21747665.
- ↑ Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Mueller PS, Edwards WD, Gertz MA (2000). "Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis". The American Journal of Medicine. 109 (3): 181–8. PMID 10974179. Unknown parameter
|month=ignored (help) - ↑ Al Suwaidi J, Velianou JL, Gertz MA; et al. (1999). "Systemic amyloidosis presenting with angina pectoris". Annals of Internal Medicine. 131 (11): 838–41. PMID 10610629. Unknown parameter
|month=ignored (help) - ↑ Yoshiki Sekijima, Shigeharu Uchiyama, Kana Tojo, Kenji Sano, Yusaku Shimizu, Toshihiko Imaeda, Yoshibonu Hoshii, Hiroyuki Kato & Shu-ichi Ikeda (2011). "High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly". Human pathology. 42 (11): 1785–1791. doi:10.1016/j.humpath.2011.03.004. PMID 21733562. Unknown parameter
|month=ignored (help)