Wild-type (senile) amyloidosis history and symptoms: Difference between revisions
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**[[Postural hypotension]] may be observed in [[Patient|patients]] with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref> | **[[Postural hypotension]] may be observed in [[Patient|patients]] with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref> | ||
**[[Chest pain]] or [[chest discomfort]] <ref name="pmid10974179">{{cite journal |author=Mueller PS, Edwards WD, Gertz MA |title=Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis |journal=[[The American Journal of Medicine]] |volume=109 |issue=3 |pages=181–8 |year=2000 |month=August |pmid=10974179 |doi= |url=}}</ref><ref name="pmid10610629">{{cite journal |author=Al Suwaidi J, Velianou JL, Gertz MA, ''et al.'' |title=Systemic amyloidosis presenting with angina pectoris |journal=[[Annals of Internal Medicine]] |volume=131 |issue=11 |pages=838–41 |year=1999 |month=December |pmid=10610629 |doi= |url=}}</ref> | **[[Chest pain]] or [[chest discomfort]] <ref name="pmid10974179">{{cite journal |author=Mueller PS, Edwards WD, Gertz MA |title=Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis |journal=[[The American Journal of Medicine]] |volume=109 |issue=3 |pages=181–8 |year=2000 |month=August |pmid=10974179 |doi= |url=}}</ref><ref name="pmid10610629">{{cite journal |author=Al Suwaidi J, Velianou JL, Gertz MA, ''et al.'' |title=Systemic amyloidosis presenting with angina pectoris |journal=[[Annals of Internal Medicine]] |volume=131 |issue=11 |pages=838–41 |year=1999 |month=December |pmid=10610629 |doi= |url=}}</ref> | ||
**Non-specific symptoms | **Non-specific symptoms such as: | ||
***[[Purpura|Periorbital purpura]] | ***[[Purpura|Periorbital purpura]] | ||
***[[Poor appetite]] | ***[[Poor appetite]] | ||
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===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
* Less common symptoms correspond to the involvement of organs or organ systems other than the heart. These can include: | * Less common [[Symptom|symptoms]] correspond to the involvement of [[Organ (anatomy)|organs]] or organ systems other than the [[heart]]. These can include: | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
History
- The clinical features of wild-type (senile) amyloidosis depend on the type of organ or organ system involved.
- Wild-type (senile) amyloidosis, classified as systemic amyloidosis, can involve any organ in the body.
- Cardiac and peripheral nerves involvement can result in clinically evident pathology.[1]
- The most commonly involved organ is the heart and majority of the patients present with signs and symptoms of heart failure.[2]
Common Symptoms
- Patients suffering from heart failure secondary to wild-type (senile) amyloidosis can present with:[2]
- Arrhythmias with associated symptoms, such as palpitations
- Syncope and presyncope
- Syncope on exertion is an ominous sign of cardiac amyloidosis, as these patients cannot augment their cardiac output due to poor filling of the ventricle (restrictive cardiomyopathy).[4]
- Postural hypotension may be observed in patients with subendothelial amyloid deposition.[5]
- Chest pain or chest discomfort [6][7]
- Non-specific symptoms such as:
Less Common Symptoms
- Less common symptoms correspond to the involvement of organs or organ systems other than the heart. These can include:
References
- ↑ Ilia G. Halatchev, Jingsheng Zheng & Jiafu Ou (2018). "Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), previously known as senile cardiac amyloidosis: clinical presentation, diagnosis, management and emerging therapies". Journal of thoracic disease. 10 (3): 2034–2045. doi:10.21037/jtd.2018.03.134. PMID 29707360. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Belinda Ng, Lawreen H. Connors, Ravin Davidoff, Martha Skinner & Rodney H. Falk (2005). "Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis". Archives of internal medicine. 165 (12): 1425–1429. doi:10.1001/archinte.165.12.1425. PMID 15983293. Unknown parameter
|month=ignored (help) - ↑ Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Mugnai G, Cicoira M, Rossi A, Vassanelli C (2011). "Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report". Experimental and Clinical Cardiology. 16 (2): 51–3. PMC 3126684. PMID 21747665.
- ↑ Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Mueller PS, Edwards WD, Gertz MA (2000). "Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis". The American Journal of Medicine. 109 (3): 181–8. PMID 10974179. Unknown parameter
|month=ignored (help) - ↑ Al Suwaidi J, Velianou JL, Gertz MA; et al. (1999). "Systemic amyloidosis presenting with angina pectoris". Annals of Internal Medicine. 131 (11): 838–41. PMID 10610629. Unknown parameter
|month=ignored (help)