Wild-type (senile) amyloidosis diagnostic study of choice: Difference between revisions
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{{Wild-type (senile) amyloidosis}} | {{Wild-type (senile) amyloidosis}} | ||
{{CMG}} | {{CMG}}{{shyam}}{{AE}}{{Sab}} | ||
==Overview== | == Overview == | ||
The diagnostic study of choice in amyloidosis is [[Tissue (biology)|tissue]] [[biopsy]] of the affected [[Organ (anatomy)|organ]]. [[Congo red|Congo Red staining]] will show apple green birefringence of the tissue sample under polarized light, and subtyping of [[Light chain|light chains]] (for light chain amyloidosis) can be done via [[mass spectrometry]]. [[Bone marrow biopsy]] and organ-specific laboratory measurements are also important ancillary [[Test|tests]]. | |||
==Diagnostic Study of Choice== | == Diagnostic Study of Choice == | ||
===Study of Choice=== | |||
=== Study of Choice === | |||
* The diagnostic study of choice in amyloidosis is [[Tissue (biology)|tissue]] [[biopsy]] of the affected [[Organ (anatomy)|organ]]. | |||
* [[Congo red|Congo Red staining]] will show apple green birefringence of the tissue sample under polarized light. | |||
* [[Mass spectrometry]] is only applicable to [[light chain]] amyloidosis. | |||
*'''Tissue biopsy''': A [[Tissue (biology)|tissue]] [[biopsy]] of the affected organ is the [[Gold standard (test)|gold standard test]] for amyloidosis. | |||
*'''Organ-specific labs''': If a particular [[Organ (biology)|organ]] is affected, laboratory measurements that are specific to that organ can be measured. For example, if there is liver involvement, [[liver function tests]] (such as [[Aspartate transaminase|AST]], [[Alanine transaminase|ALT]], [[Bilirubin|total bilirubin]], and [[alkaline phosphatase]]) should be measured.<ref name="pmid24497558">{{cite journal| author=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A| title=Update on treatment of light chain amyloidosis. | journal=Haematologica | year= 2014 | volume= 99 | issue= 2 | pages= 209-21 | pmid=24497558 | doi=10.3324/haematol.2013.087619 | pmc=3912950 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24497558 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
Latest revision as of 19:27, 17 December 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Shyam Patel [2]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[3]
Overview
The diagnostic study of choice in amyloidosis is tissue biopsy of the affected organ. Congo Red staining will show apple green birefringence of the tissue sample under polarized light, and subtyping of light chains (for light chain amyloidosis) can be done via mass spectrometry. Bone marrow biopsy and organ-specific laboratory measurements are also important ancillary tests.
Diagnostic Study of Choice
Study of Choice
- The diagnostic study of choice in amyloidosis is tissue biopsy of the affected organ.
- Congo Red staining will show apple green birefringence of the tissue sample under polarized light.
- Mass spectrometry is only applicable to light chain amyloidosis.
- Tissue biopsy: A tissue biopsy of the affected organ is the gold standard test for amyloidosis.
- Organ-specific labs: If a particular organ is affected, laboratory measurements that are specific to that organ can be measured. For example, if there is liver involvement, liver function tests (such as AST, ALT, total bilirubin, and alkaline phosphatase) should be measured.[1]
References
- ↑ Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.