Wild-type (senile) amyloidosis MRI: Difference between revisions
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==MRI== | ==MRI== | ||
===Cardiovascular Magnetic Resonance (CMR)=== | |||
*T1 sequence of CMR with the use of gadolinium can differentiate extracellular tissue thickening due to myocardial hypertrophy vs. extracellular deposition. | |||
*Using pre- and post-contrast T1 mapping, extracellular volume (ECV) can be calculated, which is a direct measurement of the cardiac interstitium.<ref>{{Cite journal | |||
| author = [[Francois-Pierre Mongeon]], [[Michael Jerosch-Herold]], [[Otavio Rizzi Coelho-Filho]], [[Ron Blankstein]], [[Rodney H. Falk]] & [[Raymond Y. Kwong]] | |||
| title = Quantification of extracellular matrix expansion by CMR in infiltrative heart disease | |||
| journal = [[JACC. Cardiovascular imaging]] | |||
| volume = 5 | |||
| issue = 9 | |||
| pages = 897–907 | |||
| year = 2012 | |||
| month = September | |||
| doi = 10.1016/j.jcmg.2012.04.006 | |||
| pmid = 22974802 | |||
}}</ref> | |||
*ECV expansion is a quantitative marker of the amyloid burden and can detect amyloid fibrils infiltration earlier than conventional testing. | |||
==References== | ==References== | ||
Revision as of 17:50, 19 December 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI
Cardiovascular Magnetic Resonance (CMR)
- T1 sequence of CMR with the use of gadolinium can differentiate extracellular tissue thickening due to myocardial hypertrophy vs. extracellular deposition.
- Using pre- and post-contrast T1 mapping, extracellular volume (ECV) can be calculated, which is a direct measurement of the cardiac interstitium.[1]
- ECV expansion is a quantitative marker of the amyloid burden and can detect amyloid fibrils infiltration earlier than conventional testing.
References
- ↑ Francois-Pierre Mongeon, Michael Jerosch-Herold, Otavio Rizzi Coelho-Filho, Ron Blankstein, Rodney H. Falk & Raymond Y. Kwong (2012). "Quantification of extracellular matrix expansion by CMR in infiltrative heart disease". JACC. Cardiovascular imaging. 5 (9): 897–907. doi:10.1016/j.jcmg.2012.04.006. PMID 22974802. Unknown parameter
|month=ignored (help)