Whipworm infection pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
*The eggs once ingested hatch in the small intestine, and the larvae enter the intestinal crypts. | *The eggs once ingested hatch in the small intestine, and the larvae enter the intestinal crypts. | ||
*The larve migrate to the the larvae proximal colon and mature into | *The larve migrate to the the larvae proximal colon and mature into adult worms. | ||
*The adult worms live in the cecum and ascending colon and attach themselves to the colonic mucosa with the anterior portions threaded into the mucosa. | |||
*The females begin to oviposit 60 to 70 days after infection and shed between 3,000 and 20,000 eggs per day. | |||
*Whipworm causes disease by colonic mucosal invasion of the adult worms and resulting in inflammation of the colonic mucosa. | *Whipworm causes disease by colonic mucosal invasion of the adult worms and resulting in inflammation of the colonic mucosa. | ||
Revision as of 14:00, 19 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
The unembryonated eggs are passed with the stool and in the soil, 1.the eggs develop into a 2-cell stage 2.an advanced cleavage stage 3. and then they embryonate 4.eggs become infective in 15 to 30 days. After ingestion (soil-contaminated hands or food), the eggs hatch in the small intestine, and release larvae 5. that mature and establish themselves as adults in the colon 6.The adult worms (approximately 4 cm in length) live in the cecum and ascending colon. The adult worms are fixed in that location, with the anterior portions threaded into the mucosa. The females begin to oviposit 60 to 70 days after infection. Female worms in the cecum shed between 3,000 and 20,000 eggs per day. The life span of the adults is about 1 year.
Transmission
Infection is acquired by the ingestion of embryonated eggs from contaminated drinking water and food.
Pathogenesis
- The eggs once ingested hatch in the small intestine, and the larvae enter the intestinal crypts.
- The larve migrate to the the larvae proximal colon and mature into adult worms.
- The adult worms live in the cecum and ascending colon and attach themselves to the colonic mucosa with the anterior portions threaded into the mucosa.
- The females begin to oviposit 60 to 70 days after infection and shed between 3,000 and 20,000 eggs per day.
- Whipworm causes disease by colonic mucosal invasion of the adult worms and resulting in inflammation of the colonic mucosa.