Waldenström's macroglobulinemia differential diagnosis: Difference between revisions

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{{Waldenström's macroglobulinemia}}
{{Waldenström's macroglobulinemia}}


===Overview===
==Overview==
Waldenström's macroglobulinemia must be differentiated from [[Multiple myeloma]], [[Chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]], [[B-cell prolymphocytic leukemia]], [[Follicular lymphoma]], [[Mantle cell lymphoma]], and Marginal zone lymphoma. <ref name="UTD"></ref>
Waldenström's macroglobulinemia must be differentiated from [[Multiple myeloma]], [[Chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]], [[B-cell prolymphocytic leukemia]], [[Follicular lymphoma]], [[Mantle cell lymphoma]], and Marginal zone lymphoma. <ref name="UTD"></ref>


===Differentiating Waldenström's macroglobulinemia from other B cell lymphoid neoplasms===
==Differentiating Waldenström's macroglobulinemia from other B cell lymphoid neoplasms==


Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:

Revision as of 15:28, 16 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]

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Overview

Waldenström's macroglobulinemia must be differentiated from Multiple myeloma, Chronic lymphocytic leukemia/small lymphocytic lymphoma, B-cell prolymphocytic leukemia, Follicular lymphoma, Mantle cell lymphoma, and Marginal zone lymphoma. [1]

Differentiating Waldenström's macroglobulinemia from other B cell lymphoid neoplasms

Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:

  • Always express CD5, usually CD23 positive[1]
  • Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)[1]
  • Express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA[1]
  • Bone marrow infiltration of small, cleaved cells that are usually paratrabecular[2]
  • Rearrangement of Bcl-2
  • Express CD138, CD38, CD79a, and VS38c and CD56(70%)[1]
  • Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and renal insufficiency[2]
  • Translocation involving chromosome 11 (t 11;14)
  • Express CD5+ and CD23-, surface IgM and IgD and cyclin D1 in majority of cases[1]
  • Infiltration of bone marrow by monomorphous, small lymphoid cells with irregular nuclei[2]
  • Marginal zone lymphoma:
  • Expresses B cell markers CD19, CD20, and CD22[1]
  • Infiltrates the bone marrow with a characteristic intertrabecular and intrasinusoidal pattern[2]
  • Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% )

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link&sectionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015
  2. 2.0 2.1 2.2 2.3 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.

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