Waldenström's macroglobulinemia bone marrow aspiration and biopsy: Difference between revisions
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==Overview== | ==Overview== | ||
A [[bone marrow aspiration]] is essential in the diagnosis of Waldenström macroglobulinemia. | A [[bone marrow aspiration]] and [[biopsy]] is essential in the [[diagnosis]] of [[Waldenström macroglobulinemia]] and shows hypercellular [[bone marrow]], Dutcher bodies, and three [[Pattern|patterns]] of [[bone marrow]] [[Infiltration (medical)|infiltration]] including lymphoplasmacytoid [[Cells (biology)|cells]], lymphoplasmacytic [[Cells (biology)|cells]] in an [[interstitial]]/[[nodular]] [[pattern]], and a polymorphous [[Infiltration (medical)|infiltrate]]. | ||
==Bone Marrow Aspirate== | ==Bone Marrow Aspirate== | ||
A [[Bone marrow aspiration|bone marrow aspirate]] is essential in the diagnosis of Waldenström macroglobulinemia. | A [[Bone marrow aspiration|bone marrow aspirate]] is essential in the [[diagnosis]] of [[Waldenström macroglobulinemia]]. | ||
Findings suggestive of Waldenström macroglobulinemia include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | Findings [[Suggestion|suggestive]] of [[Waldenström macroglobulinemia]] include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | ||
* A hypercellular bone marrow aspirate | * A hypercellular [[bone marrow]] [[aspirate]] | ||
* Lymphoplasmacytic infiltrate with characteristic [[immunophenotype]] | * Lymphoplasmacytic [[Infiltration (medical)|infiltrate]] with [[Characteristic function (probability theory)|characteristic]] [[immunophenotype]] | ||
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== Bone Marrow Biopsy == | == Bone Marrow Biopsy == | ||
* A [[bone marrow biopsy]] may be helpful in the [[diagnosis]] of [[Waldenström macroglobulinemia]]. <ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | |||
* Dutcher bodies (PAS positive intra-nuclear vacuoles containing [[IgM]] monoclonal protein) | * Findings on the [[biopsy]] [[Suggestion|suggestive]] of [[Waldenström macroglobulinemia]] include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | ||
** Characteristic feature of Waldenström macroglobulinemia | ** Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]] | ||
Three patterns of marrow involvement are described, as follows: | |||
* Lymphoplasmacytoid cells ([[Lymphoplasmacytic lymphoma|lymphoplasmacytic]] and small lymphocytes) in a nodular pattern | ** Dutcher [[Body|bodies]] ([[PAS stain|PAS]] positive intra-[[nuclear]] [[vacuoles]] containing [[IgM]] [[Monoclonal antibody|monoclonal]] [[protein]]) | ||
* Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern | ***[[Characteristic function (probability theory)|Characteristic]] [[Features (pattern recognition)|feature]] of [[Waldenström macroglobulinemia]] | ||
* A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures) | |||
* Three [[Pattern|patterns]] of [[Bone marrow|marrow]] involvement are described, as follows: | |||
** Lymphoplasmacytoid [[Cells (biology)|cells]] ([[Lymphoplasmacytic lymphoma|lymphoplasmacytic]] and small [[lymphocytes]]) in a [[nodular]] [[pattern]] | |||
** Lymphoplasmacytic [[Cells (biology)|cells]] (small [[lymphocytes]], mature [[plasma cells]], [[mast cells]]) in an [[interstitial]]/[[nodular]] [[pattern]] | |||
** A polymorphous [[Infiltration (medical)|infiltrate]] (small [[lymphocytes]], [[plasma cells]], [[plasmacytoid]] [[Cells (biology)|cells]], [[Immunoblast|immunoblasts]] with [[mitotic]] figures) | |||
==References== | ==References== | ||
Latest revision as of 18:44, 15 August 2019
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Waldenström's macroglobulinemia Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Roukoz A. Karam, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
A bone marrow aspiration and biopsy is essential in the diagnosis of Waldenström macroglobulinemia and shows hypercellular bone marrow, Dutcher bodies, and three patterns of bone marrow infiltration including lymphoplasmacytoid cells, lymphoplasmacytic cells in an interstitial/nodular pattern, and a polymorphous infiltrate.
Bone Marrow Aspirate
A bone marrow aspirate is essential in the diagnosis of Waldenström macroglobulinemia.
Findings suggestive of Waldenström macroglobulinemia include:[1]
- A hypercellular bone marrow aspirate
- Lymphoplasmacytic infiltrate with characteristic immunophenotype
 |
Bone Marrow Biopsy
- A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia. [1]
- Findings on the biopsy suggestive of Waldenström macroglobulinemia include:[1]
- Hypercellular and infiltrated with lymphoid and plasmacytoid cells
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures)
References
- ↑ 1.0 1.1 1.2 Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J; et al. (2008). "Waldenstrom macroglobulinemia". Cancer Lett. 270 (1): 95–107. doi:10.1016/j.canlet.2008.04.040. PMC 3133633. PMID 18555588.