Vitamin D deficiency differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Vitamin D deficiency must be differentiated from other diseases that cause generalized muscle and [[bone pain]], such as [[fibromyalgia]], [[chronic fatigue syndrome]], [[polymyalgia rheumatica]], and [[osteoarthritis]]. | Vitamin D deficiency must be differentiated from other diseases that cause generalized muscle and [[bone pain]], such as [[fibromyalgia]], [[chronic fatigue syndrome]], [[polymyalgia rheumatica]], and [[osteoarthritis]]. | ||
==Differentiating vitamin D deficiency from other diseases== | ==Differentiating vitamin D deficiency from other diseases== | ||
Vitamin D deficiency must be differentiated from other conditions that may cause generalized muscle and [[bone pain]]. The following table summarizes different diagnoses and how to differentiate them. | Vitamin D deficiency must be differentiated from other conditions that may cause generalized muscle and [[bone pain]]. The following table summarizes different diagnoses and how to differentiate them.<ref name="Holick2007">{{cite journal|last1=Holick|first1=Michael F.|title=Vitamin D Deficiency|journal=New England Journal of Medicine|volume=357|issue=3|year=2007|pages=266–281|issn=0028-4793|doi=10.1056/NEJMra070553}}</ref><ref name="pmid18400738">{{cite journal |vauthors=Holick MF, Chen TC |title=Vitamin D deficiency: a worldwide problem with health consequences |journal=Am. J. Clin. Nutr. |volume=87 |issue=4 |pages=1080S–6S |year=2008 |pmid=18400738 |doi= |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=18400738}}</ref><ref name="Goldenberg2004">{{cite journal|last1=Goldenberg|first1=Don L.|title=Management of Fibromyalgia Syndrome|journal=JAMA|volume=292|issue=19|year=2004|pages=2388|issn=0098-7484|doi=10.1001/jama.292.19.2388}}</ref><ref name="pmid16889509">{{cite journal |vauthors=Hollander AP, Dickinson SC, Sims TJ, Brun P, Cortivo R, Kon E, Marcacci M, Zanasi S, Borrione A, De Luca C, Pavesio A, Soranzo C, Abatangelo G, Schmoldt A, Benthe HF, Haberland G, Nakaya N, Sugano N, Nishi A, Tsukada K, Frankle RT, Stein JM, Katz B, Miledi R |title=Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees |journal=Tissue Eng. |volume=12 |issue=7 |pages=1787–98 |year=2006 |pmid=16889509 |doi=10.1089/ten.2006.12.1787 |url=}}</ref> | ||
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| style="font-weight: bold;" | [[Vitamin D deficiency]] | | style="font-weight: bold;" | [[Vitamin D deficiency]] | ||
| | | | ||
* Nonspecific musculoskeletal pain | * Nonspecific [[Myalgia|musculoskeletal pain]] | ||
* Muscle weakness | * [[Muscle weakness]] | ||
* Symmetric low back pain | * Symmetric [[low back pain]] | ||
* Throbbing bone pain | * Throbbing [[bone pain]] | ||
| | | | ||
* Low serum 25(OH)D level | * Low serum 25(OH)D level | ||
* High PTH level | * High [[Parathyroid hormone|PTH]] level | ||
|- | |- | ||
| style="font-weight: bold;" | [[Fibromyalgia]] | | style="font-weight: bold;" | [[Fibromyalgia]] | ||
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* Symptoms have been present at a similar level for at least 3 months. | * Symptoms have been present at a similar level for at least 3 months. | ||
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* Response to [[corticosteroids]] | * Response to [[corticosteroids]] | ||
|- | |- | ||
| style="font-weight: bold;" | [[Osteoarthritis]] | | style="font-weight: bold;" | [[Osteoarthritis]] | ||
| | | | ||
* Localized [[joint pain]] | * Localized [[joint pain]] | ||
* Restricted to affect joints | * Restricted to affect [[Joint|joints]] | ||
* Older at onset | * Older at onset | ||
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Latest revision as of 01:32, 21 November 2017
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Vitamin D deficiency Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Vitamin D deficiency must be differentiated from other diseases that cause generalized muscle and bone pain, such as fibromyalgia, chronic fatigue syndrome, polymyalgia rheumatica, and osteoarthritis.
Differentiating vitamin D deficiency from other diseases
Vitamin D deficiency must be differentiated from other conditions that may cause generalized muscle and bone pain. The following table summarizes different diagnoses and how to differentiate them.[1][2][3][4]
| Disease | Differentiating signs and symptoms | Diagnostic findings |
|---|---|---|
| Vitamin D deficiency |
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| Fibromyalgia |
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| Chronic fatigue syndrome | Fatigue plus 4 of the following symptoms:
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| Polymyalgia rheumatica |
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| Osteoarthritis |
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References
- ↑ Holick, Michael F. (2007). "Vitamin D Deficiency". New England Journal of Medicine. 357 (3): 266–281. doi:10.1056/NEJMra070553. ISSN 0028-4793.
- ↑ Holick MF, Chen TC (2008). "Vitamin D deficiency: a worldwide problem with health consequences". Am. J. Clin. Nutr. 87 (4): 1080S–6S. PMID 18400738.
- ↑ Goldenberg, Don L. (2004). "Management of Fibromyalgia Syndrome". JAMA. 292 (19): 2388. doi:10.1001/jama.292.19.2388. ISSN 0098-7484.
- ↑ Hollander AP, Dickinson SC, Sims TJ, Brun P, Cortivo R, Kon E, Marcacci M, Zanasi S, Borrione A, De Luca C, Pavesio A, Soranzo C, Abatangelo G, Schmoldt A, Benthe HF, Haberland G, Nakaya N, Sugano N, Nishi A, Tsukada K, Frankle RT, Stein JM, Katz B, Miledi R (2006). "Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees". Tissue Eng. 12 (7): 1787–98. doi:10.1089/ten.2006.12.1787. PMID 16889509.