Variable-sized vessel vasculitis: Difference between revisions

Revision as of 15:19, 10 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.

			Symptoms					Physical examination			Lab Findings				Imaging				Histopathology
Diseases			Clinical manifestations								Para-clinical findings									Gold standard	Additional findings
			Symptoms					Physical examination			Para-clinical findings
			Headache	Fever	Weight loss	Arthralgia	Claudication	Bruit	HTN	Focal neurological disorder	Biomarker	CBC	ESR	Other	CT scan	Angiography	Ultrasound/ Echocardiography	Other	Histopathology
Variable-vessel vasculitis	Behçet’s syndrome^[1]		-	-	-	+	-	-	+/-	-	CXCL1	Mild anemia, Neutrophilia	↑	Factor V Leiden	Focal CNS lesions	Aneurysm formation and thrombosis areas	Valve vegetations and ventricular thrombi in echocardiography	Meningoencephalitis in MRI	Lymphocytic and plasma cell invasion in the prickle cell layer of the epidermis	Clinical criteria	Genital ulcerations, Oral ulceration
	Cogan's syndrome^[2]		+/-	-	-	+/-	-	-	-	+	Anti-Hsp70 antibodies	Anemia, Thrombocytosis	↑	RF, ANA	Thickening and enhancement of both posterior sclera	Stenosis, thrombosis or more lesions in aortic root	Aortic insufficiency in echocardiography	Early interstitial keratitis by slit lamp	Muscle necrosis and atrophy resembling myositis	-	Red eye, Hearing loss, Vertigo
	Gastrointestinal disease	Inflammatory Bowel Disease^[3]	+/-	+	+	+	+	-	-	-	Anti-Saccharomyces cerevisiae antibody (ASCA), P-ANCA	Leukocytosis, Anemia	↑	Iron or vitamin deficiency, Stool OB	Mesenteric fat stranding, bowel wall enhancement, increased vascularity (comb sign)	-	Fistulas, Abscesses, Stenosis	Grossly denuded mucosa with active bleeding in colonoscopy	Crypt abscesses and mucosal ulceration, Granulomas	Endoscopy	GI bleeding
		Whipple's disease^[4]	+	+/-	+	+	+	+	+	+	CCR6, Gut-homing marker integrin β7-chain, T whippelii DNA	Mild anemia, Neutrophilia	↑	72-hour fecal fat determination	Nonspecific malabsorption	-	Hepatosplenomegaly	-	Periodic acid-Schiff–positive macrophages infiltration in lamina propria of the small bowel	Broad-spectrum PCR amplifications	Cachexia, Glossitis
		Sjögren's syndrome^[5]	-	-	+/-	+	-	-	-	-	Anti-Ro and Anti-La, Anti-alpha-fodrin antibody	Anemia, Leukopenia, Eosinophilia	↑	Hypergammaglobulinemia, Low bicarbonate level, Hypokalemia	Salt and pepper or honeycomb appearance in parotid glands	-	Multicystic or reticular pattern in atrophic salivary gland	R/O obstructions or strictures with Sialography	Focal aggregates of lymphocytes	Schirmer test	Keratoconjunctivitis, Gingival inflammation

References

↑ Yazici H, Fresko I, Yurdakul S (March 2007). "Behçet's syndrome: disease manifestations, management, and advances in treatment". Nat Clin Pract Rheumatol. 3 (3): 148–55. doi:10.1038/ncprheum0436. PMID 17334337.
↑ Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C (2015). "COGAN'S SYNDROME". Rom J Ophthalmol. 59 (1): 6–13. PMC 5729811. PMID 27373108.
↑ Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF (2016). "Inflammatory Bowel Disease". Dtsch Arztebl Int. 113 (5): 72–82. doi:10.3238/arztebl.2016.0072. PMC 4782273. PMID 26900160.
↑ Dutly F, Altwegg M (2001). "Whipple's disease and "Tropheryma whippelii"". Clin Microbiol Rev. 14 (3): 561–83. doi:10.1128/CMR.14.3.561-583.2001. PMC 88990. PMID 11432814.
↑ Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T (2017). "The Diagnosis and Treatment of Sjögren's Syndrome". Dtsch Arztebl Int. 114 (20): 354–361. doi:10.3238/arztebl.2017.0354. PMC 5471601. PMID 28610655.

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[pmid17334337-1] Yazici H, Fresko I, Yurdakul S (March 2007). "Behçet's syndrome: disease manifestations, management, and advances in treatment". Nat Clin Pract Rheumatol. 3 (3): 148–55. doi:10.1038/ncprheum0436. PMID 17334337.

[pmid27373108-2] Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C (2015). "COGAN'S SYNDROME". Rom J Ophthalmol. 59 (1): 6–13. PMC 5729811. PMID 27373108.

[pmid26900160-3] Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF (2016). "Inflammatory Bowel Disease". Dtsch Arztebl Int. 113 (5): 72–82. doi:10.3238/arztebl.2016.0072. PMC 4782273. PMID 26900160.

[pmid11432814-4] Dutly F, Altwegg M (2001). "Whipple's disease and "Tropheryma whippelii"". Clin Microbiol Rev. 14 (3): 561–83. doi:10.1128/CMR.14.3.561-583.2001. PMC 88990. PMID 11432814.

[pmid28610655-5] Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T (2017). "The Diagnosis and Treatment of Sjögren's Syndrome". Dtsch Arztebl Int. 114 (20): 354–361. doi:10.3238/arztebl.2017.0354. PMC 5471601. PMID 28610655.

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@@ Line 1: / Line 1: @@
 __NOTOC__
 {{CMG}}; {{AE}} {{EG}}
 <span style="font-size:85%">'''Abbreviations:'''
 ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
+<small>
 {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
 ! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
@@ Line 34: / Line 36: @@
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-|-
-! rowspan="30" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[ANCA-associated vasculitis]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Microscopic polyangiitis]]<ref name="pmid20688249">{{cite journal| author=Chung SA, Seo P| title=Microscopic polyangiitis. | journal=Rheum Dis Clin North Am | year= 2010 | volume= 36 | issue= 3 | pages= 545-58 | pmid=20688249 | doi=10.1016/j.rdc.2010.04.003 | pmc=2917831 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20688249  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (40%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (60%)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normocytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Proteinuria]], [[RBC casts|Erythrocyte casts]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Suspected [[pancreatitis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric]] [[angiography]] for differentiating from [[polyarteritis nodosa]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral nodular, and patchy [[Opacity|opacities]] in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Glomerulonephritis]] with focal [[necrosis]], crescent formation, and lack or paucity of [[immunoglobulin]] deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Granulomatosis with polyangiitis|Granulomatosis with polyangiitis (Wegener’s)]]<ref name="pmid27195187">{{cite journal| author=Kubaisi B, Abu Samra K, Foster CS| title=Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations. | journal=Intractable Rare Dis Res | year= 2016 | volume= 5 | issue= 2 | pages= 61-9 | pmid=27195187 | doi=10.5582/irdr.2016.01014 | pmc=4869584 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27195187  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (90%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (10%)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia|Normochromic normocytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Consolidation (medicine)|Consolidation]], Patchy or diffuse [[Ground glass opacification on CT|ground-glass opacities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occlusion]] or [[stenosis]] of [[LAD]] and [[RCA]] in [[coronary angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Single or multiple [[nodules]] and [[Mass|masses]] with [[cavitation]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parenchymal]] [[necrosis]], [[Granulomatous]] [[inflammation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Conjunctivitis]],
-[[Episcleritis]],
-[[Uveitis]],
-[[Optic nerve]] vasculitis
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eosinophilic granulomatosis with polyangiitis|Eosinophilic granulomatosis with polyangiitis]]
-[[Eosinophilic granulomatosis with polyangiitis|(Churg-Strauss)]]<ref name="pmid16612766">{{cite journal |vauthors=Keogh KA, Specks U |title=Churg-Strauss syndrome |journal=Semin Respir Crit Care Med |volume=27 |issue=2 |pages=148–57 |date=April 2006 |pmid=16612766 |doi=10.1055/s-2006-939518 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]] (40%), Eotaxin-3
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Proteinuria]], [[RBC casts|Erythrocyte casts]], ↑[[Immunoglobulin E|IgE]] levels
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Significant enlargement of peripheral [[pulmonary arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myocardial ischemia]] and [[Myocardial infarction|infarction]] in [[coronary angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Congestive heart failure|Congestive heart failure (CHF)]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Extensive air-space [[Opacity|opacities]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small [[necrotizing]] [[granulomas]] with  [[eosinophilic]] core surrounded by [[macrophages]] and [[Epithelioid cell|epithelioid giant cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Allergic rhinitis]], [[Asthma]], [[Urticaria|Urticarial rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hydralazine]]-associated [[ANCA-associated vasculitis]]<ref name="pmid23316942">{{cite journal| author=Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW| title=Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue=  | pages= 20 | pmid=23316942 | doi=10.1186/1752-1947-7-20 | pmc=3565908 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23316942  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]], Anti-histone antibodies
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[pulmonary]] infiltrates
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Pauci-immune [[necrotizing]] and [[crescentic glomerulonephritis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sinusitis]], [[Hemoptysis]]
-|-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Immune complexes|Immune complex]] small-vessel vasculitis
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Goodpasture disease|Anti-glomerular basement membrane disease]]<ref name="pmid28515156">{{cite journal |vauthors=McAdoo SP, Pusey CD |title=Anti-Glomerular Basement Membrane Disease |journal=Clin J Am Soc Nephrol |volume=12 |issue=7 |pages=1162–1172 |date=July 2017 |pmid=28515156 |doi=10.2215/CJN.01380217 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypochromic anemia|Hypochromic microcytic anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C3 (complement)|C3]] level
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal [[kidneys]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Alveolar]] infiltrates spreading from the [[hilum]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cellular crescents in the [[glomeruli]], [[Pulmonary hemorrhage|Intra-alveolar hemorrhages]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cryoglobulinemia|Cryoglobulinemic vasculitis]]<ref name="pmid16344620">{{cite journal |vauthors=Ferri C, Mascia MT |title=Cryoglobulinemic vasculitis |journal=Curr Opin Rheumatol |volume=18 |issue=1 |pages=54–63 |date=January 2006 |pmid=16344620 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C4A|C4 component]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], [[hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O underlying [[malignancy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bacterial endocarditis]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interstitial]] involvement or [[pleural effusions]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HCV]]-associated [[proteins]] in [[vasculitic]] [[skin]], Intraluminal [[cryoglobulin]] deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrocyanosis]], [[Retinal]] [[hemorrhage]], [[Purpura]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]<ref name="pmid28810602">{{cite journal| author=Guo QY, Wu M, Wang YW, Sun GD| title=Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. | journal=Exp Ther Med | year= 2017 | volume= 14 | issue= 2 | pages= 1395-1398 | pmid=28810602 | doi=10.3892/etm.2017.4671 | pmc=5525644 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28810602  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Cryoglobulins]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C4A|Serum C4]], Positive [[RF]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vasculitic]] skin, [[Antigen]] infilteration in [[lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Palpable [[purpura]], [[Microscopic hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]<ref name="pmid26990342">{{cite journal |vauthors=Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK |title=IgA vasculitis (Henoch-Schönlein purpura) |journal=Dermatol. Online J. |volume=21 |issue=12 |pages= |date=December 2015 |pmid=26990342 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], [[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occult blood|Stool OB]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[bowel]] wall thickness, [[Hematoma|hematomas]], [[peritoneal fluid]], and [[intussusception]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated loops of [[bowel]] consistent in [[abdominal X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytoclastic vasculitis]] in postcapillary [[venules]] with [[IgA]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Purpura|Palpable purpura]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]<ref name="pmid22328958">{{cite journal| author=Buck A, Christensen J, McCarty M| title=Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. | journal=J Clin Aesthet Dermatol | year= 2012 | volume= 5 | issue= 1 | pages= 36-46 | pmid=22328958 | doi= | pmc=3277093 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22328958  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C11orf1|C1q]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], ↓[[C10orf10|C1q]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Deposits of [[immunoglobulins]], [[complement]], or [[fibrin]] around [[blood vessels]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]],
-[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]], [[Hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute mesenteric ischemia]]<ref name="pmid24267504">{{cite journal |vauthors=Sise MJ |title=Acute mesenteric ischemia |journal=Surg. Clin. North Am. |volume=94 |issue=1 |pages=165–81 |date=February 2014 |pmid=24267504 |doi=10.1016/j.suc.2013.10.012 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FABP1|I-FABP]], [[GSTA1|Alpha-GST]], [[Ischemia-modified albumin (IMA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], ↑[[Hematocrit|HCT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | ↑[[Amylase]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bowel]] wall thickening, [[Pneumatosis intestinalis|Intestinal pneumatosis]], [[Mesenteric ischemia|Portomesenteric]] thrombosis
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric vein thrombosis|Mesenteric venous thrombosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Artery|Arterial]] [[stenosis]] or occlusion of the [[Celiac artery|celiac]] or [[superior mesenteric arteries]] in [[duplex ultrasound]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ileus]] with distended loops of [[bowel]], [[Bowel]] wall thickening in [[abdominal X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Superficial [[Mucosal bleeding|mucosal hemorrhage]], [[edema]] and [[necrosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Abdominal pain]], [[Distension]], [[Absent bowel sounds]]
-|-
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular diseases|Cardiovascular disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infective Endocarditis]]<ref name="pmid19665088">{{cite journal| author=McDonald JR| title=Acute infective endocarditis. | journal=Infect Dis Clin North Am | year= 2009 | volume= 23 | issue= 3 | pages= 643-64 | pmid=19665088 | doi=10.1016/j.idc.2009.04.013 | pmc=2726828 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19665088  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NT-proBNP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia|Normochromic-normocytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypergammaglobulinemia|Hyperglobulinemia]], [[Cryoglobulinemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Metastatic]] [[infections]], such as [[Splenic infarction|splenic infarct]], [[Renal infarct|renal infarcts]], or [[psoas abscess]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]], [[abscess]], or new dehiscence of a [[Prosthetic valves|prosthetic valve]]<nowiki/>in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vertebral osteomyelitis]] in [[Magnetic resonance imaging|MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]] or [[Abscess|intracardiac abscess]] demonstrating active [[endocarditis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Echocardiography]] ([[TTE]])
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Janeway lesions]], [[Osler nodes]], [[Roth's spot|Roth spots]], [[Vertebral osteomyelitis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Leukocytoclastic vasculitis|Leukocytoclastic Vasculitis]]<ref name="pmid26176572">{{cite journal| author=Einhorn J, Levis JT| title=Dermatologic Diagnosis: Leukocytoclastic Vasculitis. | journal=Perm J | year= 2015 | volume= 19 | issue= 3 | pages= 77-8 | pmid=26176572 | doi=10.7812/TPP/15-001 | pmc=4500485 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26176572  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgM]], [[IgA]], [[Immunoglobulin G|IgG]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular]] [[stenosis]] and [[obstruction]] in visceral [[Angiogram|angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Perivascular [[inflammatory]] infiltrate of [[neutrophils]] with leukocytoclasia (releasing [[nuclear]] debris)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Palpable purpura]], [[Petechiae]]
-|-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Langerhans Cell Histiocytosis]]<ref name="pmid18572052">{{cite journal |vauthors=Margo CE, Goldman DR |title=Langerhans cell histiocytosis |journal=Surv Ophthalmol |volume=53 |issue=4 |pages=332–58 |date=2008 |pmid=18572052 |doi=10.1016/j.survophthal.2008.04.007 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD1a]], CD207,[[BRAF (gene)|BRAF-V600E]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary cystic lymphangiectasis|Pulmonary cysts]] and [[Pulmonary nodule|nodules]], [[Lytic|Bone lytic lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebellum]] and [[pons]] hyperintensity in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birbeck granules]] by [[electron microscopy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Brown to purplish [[papules]], [[Eczematous Scaling|Eczematous rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non small cell lung cancer|Non-Small Cell Lung Cancer]]<ref name="pmid18452692">{{cite journal| author=Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA| title=Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 5 | pages= 584-94 | pmid=18452692 | doi=10.4065/83.5.584 | pmc=2718421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18452692  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[EGFR]], ''[[ROS1]],'' [[Anaplastic lymphoma kinase|EML4-''ALK'']],  [[PD-L1]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]], [[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary|Pulmonary lesion]] or [[mass]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] marginal [[lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]] and response to treatment in [[Positron emission tomography|PET-CT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Adenocarcinoma of the lung pathophysiology|Adenocarcinoma]], [[Squamous cell carcinoma of the lung pathophysiology|Squamous cell carcinoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Small cell lung cancer|Small Cell Lung Cancer]]<ref name="pmid16226617">{{cite journal |vauthors=Jackman DM, Johnson BE |title=Small-cell lung cancer |journal=Lancet |volume=366 |issue=9494 |pages=1385–96 |date=2005 |pmid=16226617 |doi=10.1016/S0140-6736(05)67569-1 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |''[[P53 (protein)|p53]],'' [[Thyroid transcription factor-1|Thyroid transcription factor-1 (TTF1)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large [[hilar]] mass with bulky [[mediastinal]] [[adenopathy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Endobronchial [[ultrasound]] (EBUS)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Standard [[Staging (pathology)|staging]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spindled cells with dark [[nuclei]], scant [[cytoplasm]], and fine, granular [[Chromatin|nuclear chromatin]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary Infarction]]<ref name="pmid15821192">{{cite journal |vauthors=Parambil JG, Savci CD, Tazelaar HD, Ryu JH |title=Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy |journal=Chest |volume=127 |issue=4 |pages=1178–83 |date=April 2005 |pmid=15821192 |doi=10.1378/chest.127.4.1178 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[D-dimer]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[leukocytosis]], Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypoxemia]], [[Hypocarbia]] or [[Hypercarbia]],  [[Respiratory alkalosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary embolism]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-[[density]] filling defect within the [[pulmonary artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] infiltrates, [[atelectasis]], and [[pleural effusions]] in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarct]] induced [[apoptosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary artery]] [[angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Renal disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute poststreptococcal glomerulonephritis|Acute Poststreptococcal Glomerulonephritis]]<ref name="pmid25554106">{{cite journal |vauthors=VanDeVoorde RG |title=Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis |journal=Pediatr Rev |volume=36 |issue=1 |pages=3–12; quiz 13 |date=January 2015 |pmid=25554106 |doi=10.1542/pir.36-1-3 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antistreptococcal antibodies|Antistreptolysin-O (ASO) titers]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal to slightly enlarged [[kidneys]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central venous pressure|Central venous]] congestion in a [[hilar]] pattern  in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypercellularity of [[Endothelial cells|endothelial]] and [[mesangial cells]], Infiltration of the [[glomerular]] tuft with [[polymorphonuclear cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]]
-|-
-! rowspan="8" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hemolytic-uremic syndrome|Hemolytic-Uremic Syndrome]]<ref name="pmid11691946">{{cite journal |vauthors=Corrigan JJ, Boineau FG |title=Hemolytic-uremic syndrome |journal=Pediatr Rev |volume=22 |issue=11 |pages=365–9 |date=November 2001 |pmid=11691946 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C5a|C5b-9]], [[ADAMTS13]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Reticulocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thalami]], [[brainstem]], or [[cerebellum]] abnormality
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[microangiopathy]] or [[hypertension]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypoechoic [[kidney]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abnormal hyperintensity in the [[Brain|brain cisterns]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thromboses|Microthromboses]] include [[Fibrin|fibrin thrombi]] that may occlude the [[glomerular]] tuft
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Proteinuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia (CLL)]]<ref name="pmid15561682">{{cite journal |vauthors=Byrd JC, Stilgenbauer S, Flinn IW |title=Chronic lymphocytic leukemia |journal=Hematology Am Soc Hematol Educ Program |volume= |issue= |pages=163–83 |date=2004 |pmid=15561682 |doi=10.1182/asheducation-2004.1.163 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD5]], [[CD19]], [[CD20]], IgV<sub>H</sub>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Absolute [[lymphocytosis]], Smudge cells
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Flow cytometry]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large atypical [[Cells (biology)|cells]], cleaved cells, and [[prolymphocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chromosomal]] and [[genetic testing]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Multiple myeloma|Multiple Myeloma]]<ref name="pmid28318212">{{cite journal |vauthors=Michels TC, Petersen KE |title=Multiple Myeloma: Diagnosis and Treatment |journal=Am Fam Physician |volume=95 |issue=6 |pages=373–383 |date=March 2017 |pmid=28318212 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Light chain|Ig light chain]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Leukopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone marrow aspiration]] and [[biopsy]], ↑[[Cr]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Osseous]] involvement and [[Lytic|lytic lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Peripheral zone of increased [[vascularity]] in lesions
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Punched-out lesion in [[X-ray|skull X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clonal proliferation of [[plasma cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Protein electrophoresis]] plus conventional [[X-rays]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Constipation]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypereosinophilic syndrome|Hypereosinophilic Syndrome]]<ref name="pmid19630574">{{cite journal |vauthors=Klion A |title=Hypereosinophilic syndrome: current approach to diagnosis and treatment |journal=Annu. Rev. Med. |volume=60 |issue= |pages=293–306 |date=2009 |pmid=19630574 |doi=10.1146/annurev.med.60.062107.090340 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgE]], [[CD117]] with [[CD2]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[tryptase]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphadenopathy]] and [[splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracardiac thrombus|Intracardiac thrombi]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Reticulin|Reticulin stain]] for [[myelofibrosis]] and [[tryptase]] staining for [[mast cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splinter hemorrhages]], [[Raynaud phenomenon]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]<ref name="pmid22835603">{{cite journal |vauthors=Shankland KR, Armitage JO, Hancock BW |title=Non-Hodgkin lymphoma |journal=Lancet |volume=380 |issue=9844 |pages=848–57 |date=September 2012 |pmid=22835603 |doi=10.1016/S0140-6736(12)60605-9 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-myc|MYC]], [[BCL2-like 1 (gene)|BCL2]], [[BCL6]], and [[TP53]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytosis]], [[Anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Enlarged [[Lymph node|lymph nodes]], [[Hepatosplenomegaly]], Filling defects in the [[liver]] and [[spleen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mediastinal lymphadenopathy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small cleaved or noncleaved, intermediate, or large cell with a follicular or diffuse pattern
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Surgically excised tissue [[biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Testicular mass]], [[Skin lesions|Skin lesion]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Serum sickness|Serum Sickness]]<ref name="pmid2867672">{{cite journal |vauthors=Lin RY |title=Serum sickness syndrome |journal=Am Fam Physician |volume=33 |issue=1 |pages=157–62 |date=January 1986 |pmid=2867672 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IL-1]], [[IL-6]], [[TNF]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Gammopathy|Polyclonal gammopathy]], ↑[[Cr]], [[Cryoglobulinemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Arteritic lesions are focal, [[necrotizing]], and [[inflammatory]]  involving all layers of the [[artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Skin rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]<ref name="pmid25535423">{{cite journal| author=Venugopal A| title=Disseminated intravascular coagulation. | journal=Indian J Anaesth | year= 2014 | volume= 58 | issue= 5 | pages= 603-8 | pmid=25535423 | doi=10.4103/0019-5049.144666 | pmc=4260307 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25535423  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrin degradation product|Fibrin degradation product (FDP)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Schistocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[aPTT]] and [[PT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracranial hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ischemia]] and [[necrosis]] due to [[Fibrin|fibrin deposition]] in small and medium-sized [[vessels]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Cyanosis|Acral cyanosis]], [[Hemorrhagic]] skin [[Infarction|infarctions]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Idiopathic thrombocytopenic purpura|Idiopathic Thrombocytopenic Purpura]]<ref name="pmid27441004">{{cite journal| author=Nomura S| title=Advances in Diagnosis and Treatments for Immune Thrombocytopenia. | journal=Clin Med Insights Blood Disord | year= 2016 | volume= 9 | issue=  | pages= 15-22 | pmid=27441004 | doi=10.4137/CMBD.S39643 | pmc=4948655 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27441004  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FCGR2B|FC gamma receptors (FCGR) IIb]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HIV]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O other causes
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O [[splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased number of normal morphologic [[megakaryocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Purpura]]
-|-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sarcoidosis]]<ref name="pmid27454074">{{cite journal| author=Chiarchiaro J, Chen BB, Gibson KF| title=New molecular targets for the treatment of sarcoidosis. | journal=Curr Opin Pulm Med | year= 2016 | volume= 22 | issue= 5 | pages= 515-21 | pmid=27454074 | doi=10.1097/MCP.0000000000000304 | pmc=5152532 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27454074  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[IL-2]] and [[Interferon gamma|IFN-γ]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Angiotensin-converting enzyme|ACE]], ↑[[Vitamin D|1, 25-dihydroxyvitamin D]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Active [[alveolitis]] or [[fibrosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[Adenopathy|hilar adenopathy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granuloma|Noncaseating granulomas (NCGs)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heart block]], [[Ocular disease|Ocular lesion]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Legionella Infections|Legionella Infection]]<ref name="pmid12491204">{{cite journal |vauthors=Murdoch DR |title=Diagnosis of Legionella infection |journal=Clin. Infect. Dis. |volume=36 |issue=1 |pages=64–9 |date=January 2003 |pmid=12491204 |doi=10.1086/345529 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cytokine|Inflammatory cytokines]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]], [[Thrombocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[Fibrin degradation product|FDP]], [[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pleural effusion]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Nonspecific and indistinguishable [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Intra-[[alveolar]] [[inflammation]], [[Abscesses|Microabscesses]] in the [[parenchyma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum culture]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Diarrhea]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic lupus erythematosus]]<ref name="Tsokos2011">{{cite journal|last1=Tsokos|first1=George C.|title=Systemic Lupus Erythematosus|journal=New England Journal of Medicine|volume=365|issue=22|year=2011|pages=2110–2121|issn=0028-4793|doi=10.1056/NEJMra1100359}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti dsDNA]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Leukopenia]], [[Lymphopenia]], [[Anemia]],  [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑[[ALT]] or [[AST]], [[Proteinuria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Interstitial lung disease, [[Pneumonitis]], [[Pulmonary emboli]], [[Hemorrhage|Alveolar hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]], [[pulmonary hypertension]], or verrucous [[Libman-Sacks endocarditis]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central nervous system|Central nervous system (CNS)]] [[Systemic lupus erythematosus|lupus]] white-matter changes in [[MRI]]
-! align="center"  style="padding: 5px 5px; background: #F5F5F5;" |Staging [[lupus nephritis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti-dsDNA antibody test]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rashes]] or [[photosensitivity]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rheumatoid arthritis]]<ref name="pmid16824912">{{cite journal| author=Scott JT| title=The gold standard in rheumatoid arthritis. | journal=J R Soc Med | year= 1991 | volume= 84 | issue= 9 | pages= 513-4 | pmid=1682491 | doi= | pmc=1293405 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1682491  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[RF]], [[Anti-citrullinated protein antibody|Anti-CCP antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑[[ALT]] or [[AST]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fractures|Microfractures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint (anatomy)|Effusions in joints]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Basilar invagination with [[cranial]] migration of an eroded [[Odontoid process|odontoid]] peg in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Influx of [[inflammatory cells]] into the [[synovial membrane]], with  [[angiogenesis]], proliferation of chronic [[inflammatory cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled [[Anti-citrullinated protein antibody|anti-CCP antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid nodules]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Relapsing polychondritis]]<ref name="pmid27708954">{{cite journal| author=Emmungil H, Aydın SZ| title=Relapsing polychondritis. | journal=Eur J Rheumatol | year= 2015 | volume= 2 | issue= 4 | pages= 155-159 | pmid=27708954 | doi=10.5152/eurjrheum.2015.0036 | pmc=5047229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27708954  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cryoglobulins]], [[ANA]], [[C-ANCA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calcification]] of [[Cartilaginous|cartilaginous structures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]] and degree of [[aortic regurgitation]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheal stenosis]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chondrolysis, [[Chondritis]],  Perichondritis
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with imaging
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ear pain]] and redness, [[Polyarthritis]]
-|-
-! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
-! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
-! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
 |-
 ! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Variable-vessel vasculitis
@@ Line 818: / Line 149: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Schirmer's test|Schirmer test]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Keratoconjunctivitis]], [[Gingival|Gingival inflammation]]
-|-
-! rowspan="6" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Single-organ vasculitis
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary [[central nervous system]] [[vasculitis]]<ref name="pmid16575852">{{cite journal |vauthors=Benseler SM, Silverman E, Aviv RI, Schneider R, Armstrong D, Tyrrell PN, deVeber G |title=Primary central nervous system vasculitis in children |journal=Arthritis Rheum. |volume=54 |issue=4 |pages=1291–7 |date=April 2006 |pmid=16575852 |doi=10.1002/art.21766 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Von Willebrand factor (vWF)|von Willebrand factor antigen (vWF)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CSF]] [[pleocytosis]], predominantly [[lymphocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[Infarction|infarcts]] or [[hemorrhages]] with [[mass effect]], or [[hydrocephalus]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]] in [[circle of Willis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Progression of the disease or response to therapy in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chronic [[granulomatous]] [[inflammation]] and [[giant cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rash]], [[Purpura]]
-|-
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infectious disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Aspergillosis]]<ref name="pmid10194462">{{cite journal| author=Latgé JP| title=Aspergillus fumigatus and aspergillosis. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 310-50 | pmid=10194462 | doi= | pmc=88920 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194462  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergillus]] [[nucleic acid]] in [[blood]], [[Galactomannan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[Immunoglobulin E|IgE]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergilloma]] mass within a cavity
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mass effect]] [[stenosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergilloma]] mass within the brain in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Septate [[hyphae]], branching at acute angles, and tissue [[necrosis]] with  [[Granuloma|granulomata]] and [[blood vessel]] invasion
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Aspergilloma]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Histoplasmosis]]<ref name="pmid20445761">{{cite journal| author=Guimarães AJ, Nosanchuk JD, Zancopé-Oliveira RM| title=DIAGNOSIS OF HISTOPLASMOSIS. | journal=Braz J Microbiol | year= 2006 | volume= 37 | issue= 1 | pages= 1-13 | pmid=20445761 | doi=10.1590/S1517-83822006000100001 | pmc=2863343 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20445761  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Alkaline phosphatase|ALP]], ↑[[LDH]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[histoplasmosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Valvular Diseases|Valvular involvement]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PFTs|PFT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Presence of [[yeast]] forms in tissue through [[Hematoxylin and eosin stain|hematoxylin and eosin staining]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum cultures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]], [[Mediastinitis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Herpes Simplex Encephalitis]]<ref name="pmid9163027">{{cite journal |vauthors=Sköldenberg B |title=Herpes simplex encephalitis |journal=Scand J Infect Dis Suppl |volume=100 |issue= |pages=8–13 |date=1996 |pmid=9163027 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Herpes simplex virus|HSV]] [[DNA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[lymphocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CSF]] [[pleocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-density lesions in the [[Temporal lobe|temporal]] and/or [[frontal lobe]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemorrhagic]] lesion in [[white matter]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Multinucleated giant cell|Multinuclear giant cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PCR]] or [[brain biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizures]],
-[[Vomiting]]
-|-
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic diseases|Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eclampsia]]<ref name="pmid21822394">{{cite journal| author=Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM| title=Pre-eclampsia: pathophysiology, diagnosis, and management. | journal=Vasc Health Risk Manag | year= 2011 | volume= 7 | issue=  | pages= 467-74 | pmid=21822394 | doi=10.2147/VHRM.S20181 | pmc=3148420 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21822394  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular endothelial growth factor|VEGF]], [[PlGF]], Soluble [[FLT1|FLT-1]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Schistocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Bilirubin]], ↓[[Haptoglobin]], ↑[[Lactate dehydrogenase|LDH]], ↑[[Creatinine|Cr]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cortical hypodense areas in the [[Occipital lobe|occipital lobes]], Diffuse [[cerebral edema]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fetal growth retardation|Poor fetal growth]], [[Oligohydramnios]], Abnormal [[umbilical artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased signal at the [[Gray matter|gray-white matter junction]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urinalysis|24-hour urine study]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizure]], [[Edema]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581">{{cite journal| author=Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X| title=Fibromuscular dysplasia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 28 | pmid=17555581 | doi=10.1186/1750-1172-2-28 | pmc=1899482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17555581  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Transforming growth factor β|Transforming growth factor β (TGF-β)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[stenosis]] and [[Dilatation|dilatations]] in [[CT angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] in the [[renal arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Luminal narrowing alternating with [[dilatation]] (Beads sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[concentric]], long-segment [[tubular]] [[stenosis]] or outpouching in [[MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Fibrodysplastic changes, [[Collagen]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Spontaneous coronary artery dissection|Spontaneous coronary artery dissection (SCAD)]]
 |-
 |}
+</small>
 ==References==
 {{Reflist|2}}

Variable-sized vessel vasculitis: Difference between revisions

Revision as of 15:19, 10 April 2018

References

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